Fang, WenxiaRaimi, Olawale GBlair, David EHarrison, Justin RLockhart, Deborah E ATorrie, Leah SRuda, Gian FilippoWyatt, Paul GGilbert, Ian Hvan Aalten, Daan M F2021-02-022021-02-022015-06-19Fang, W, Raimi, O G, Blair, D E, Harrison, J R, Lockhart, D E A, Torrie, L S, Ruda, G F, Wyatt, P G, Gilbert, I H & van Aalten, D M F 2015, 'N -myristoyltransferase is a cell wall target in Aspergillus fumigatus', ACS Chemical Biology, vol. 10, no. 6, pp. 1425-1434. https://doi.org/10.1021/cb50086471554-8929PubMedCentral: PMC4477619ORCID: /0000-0002-4262-3842/work/189632471https://hdl.handle.net/2164/15765The authors would like to thank the European Synchrotron Radiation facility (ESRF), Grenoble, for beamline time. We thank J. James of the College of Life Sciences Microscopy Facility for his help with electron microscopy. We also thank F. Eisenhaber, Bioinformatics Institute Singapore, for predicting myristoylated proteins. This work was funded by an MRC Programme Grant (M004139) and a Wellcome Trust Senior Research Fellowship (WT087590MA) to D.M.F.v.A. D.E.A.L was supported by an MRC Clinical Research Training Fellowship (G1100430). We also would like to acknowledge the Wellcome Trust (WT077705, WT083481) for support. Supporting Figures S1−S3, Supporting Tables S1−S4, and further details of experimental procedures. This material is available free of charge via the Internet from http://pubs.acs.org.102101069engAcyltransferasesAminopyridinesAntifungal AgentsAspergillus fumigatusCatalytic DomainCell WallCrystallography, X-RayFungal ProteinsKineticsMicrobial Sensitivity TestsProtein BindingProtein Processing, Post-TranslationalProtein Structure, SecondaryPyrazolesStructure-Activity RelationshipSulfonamidesJournal ArticleResearch Support, Non-U.S. Gov'tQD ChemistryMedical Research Council (MRC)M004139G1100430Wellcome TrustWT087590MAWT077705WT083481Supplementary DataQDJournal article10.1021/cb5008647106