Skeggs, AndrewMcKeever, TriciaDuley, LeliaMitchell, EleanorBradshaw, LucyMortimer, KevinWalker, SamanthaParrott, SteveWilson, AndrewPavord, IanBrightling, ChrisThomas, MikePrice, DavidDevereux, GrahamHiggins, BernardHarrison, TimHaydock, Rebecca2016-10-272016-10-272016-10-13Skeggs, A, McKeever, T, Duley, L, Mitchell, E, Bradshaw, L, Mortimer, K, Walker, S, Parrott, S, Wilson, A, Pavord, I, Brightling, C, Thomas, M, Price, D, Devereux, G, Higgins, B, Harrison, T & Haydock, R 2016, 'FourFold Asthma Study (FAST) : a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations', Trials, vol. 17, 499. https://doi.org/10.1186/s13063-016-1608-61745-6215http://hdl.handle.net/2164/7607This project was funded by the National Institute for Health Research Health Technology Assessment Programme (project number 10/143/01). The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the Health Technology Assessment Programme, NIHR, NHS or the Department of Health. The trial is sponsored by the University of Nottingham and supported by the NIHR Clinical Research Network. The Trial Management Committee we would like to thank all of the coapplicants on the grant application and protocol for their scientific contribution to the trial, and the East Midlands Clinical Research Network (CRN) which is acting as lead CRN for the study. We would also like to thank the participating local CRNs that helped to facilitate primary care research in their region and all the participating research sites for their contribution to recruitment.1867940engasthmaexacerbationself-management planinhaled corticosteroidsoral corticosteroids Randomised controlled trialfourfoldprotocolprimary careR MedicineRJournal article10.1186/s13063-016-1608-617