Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways

Al-Wahaibi, Lamya H.Mohammed, Anber F.Abdelrahman, Mostafa H.Trembleau, LaurentYoussif, Bahaa G.M.2023-04-052023-04-052023-02Al-Wahaibi, L H, Mohammed, A F, Abdelrahman, M H, Trembleau, L & Youssif, B G M 2023, 'Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFR T790M /BRAF V600E Pathways', Molecules, vol. 28, no. 3, 1269. https://doi.org/10.3390/molecules280312691420-3049ORCID: /0000-0001-6376-9077/work/132961163https://hdl.handle.net/2164/20416Funding Information: This work was funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project Number (PNURSP2023R3), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.2346311engSDG 3 - Good Health and Well-beinganticancerBRAFindolemelanomamutant EGFRpyrroleQD ChemistryAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistrySupplementary Informationhttps://www.mdpi.com/article/10.3390/molecules28031269/s1QDDesign, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E PathwaysJournal article10.3390/molecules28031269http://www.scopus.com/inward/record.url?scp=85147964113&partnerID=8YFLogxK283