High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria

Cao, HuanAntonopoulos, AristotelisHenderson, SadieWassall, Heather J.hBrewin, JohnMasson, AlannaShepherd, JennaKonieczny, GabrielaPatel, BhinalWilliams, Maria-LouiseDavie, AdamForrester, Megan AmyHall, LindsayMinter, BeverleyTampakis, DimitrisMoss, MichaelLennon, CharlottePickford, WendyErwig, LarsRobertson, BeverleyDell, AnneBrown, Gordon DouglasWilson, HeatherRees, David C.Haslam, Stuart MRowe, J. AlexandraBarker, RobertVickers, Mark2024-04-112024-04-112020-11-27Cao, H, Antonopoulos, A, Henderson, S, Wassall, H J H, Brewin, J, Masson, A, Shepherd, J, Konieczny, G, Patel, B, Williams, M-L, Davie, A, Forrester, M A, Hall, L, Minter, B, Tampakis, D, Moss, M, Lennon, C, Pickford, W, Erwig, L, Robertson, B, Dell, A, Brown, G D, Wilson, H, Rees, D C, Haslam, S M, Rowe, J A, Barker, R & Vickers, M 2020, 'High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria', bioRxiv. https://doi.org/10.1101/2020.11.26.399402ORCID: /0000-0002-3154-1040/work/86449712ORCID: /0000-0002-1407-7274/work/91891238https://hdl.handle.net/2164/23221Acknowledgements We are grateful for the assistance provided by both the Microscopy and Histology Core Facility, and the Iain Fraser Cytometry Centre, at the University of Aberdeen. We thank Ann Wheeler and Matt Pearson from Edinburgh Super-Resolution Imaging Consortium for technical support with 3D SIM microscopy. We also thank Janet A. Willment and Bernard Kerscher, supervised by G.D.B., for providing the Fc fusion proteins, Jeanette A. Wagener, supervised by Neil A.R.G. Gow, for providing high purity chitin, Jan Westland for obtaining blood samples and Paul Crocker for useful discussions. Principal funding for this project was provided by Wellcome Trust grant 094847 (R.N.B, L.P.E, M.A.V). In addition, support was provided by Biotechnology and Biological Sciences Research Council grants BBF0083091 (A.D. and S.M.H.) and BBK0161641 (A.D. and S.M.H.), Wellcome Trust grant 082098 (A.D.), Wellcome Trust grants 97377, 102705 (G.D.B) and funding for the MRC Centre for Medical Mycology at the University of Aberdeen MR/N006364/1 (G.D.B).11341132engOutside of REF 2029 publication periodSDG 3 - Good Health and Well-beingR MedicineQR180 ImmunologyRQR180High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malariaJournal article10.1101/2020.11.26.399402