Backhouse, Ellen V.Shenkin, Susan DMcIntosh, Andrew M.Bastin, Mark EWhalley, Heather C.Valdez Hernandez, MariaMuñoz Maniega, SusanaHarris, Matthew A.Stolicyn, AleksCampbell, ArchieSteele, DouglasSteele, DouglasWaiter, GordonSandu-Giuraniuc, Anca-LarisaWaymont, Jennifer M JMurray, AlisonCox, Simon R.de Rooij, SusanneRoseboom, Tessa J.Wardlaw, Joanna M.2022-02-022022-02-022021-09-28Backhouse, E V, Shenkin, S D, McIntosh, A M, Bastin, M E, Whalley, H C, Valdez Hernandez, M, Muñoz Maniega, S, Harris, M A, Stolicyn, A, Campbell, A, Steele, D, Steele, D, Waiter, G, Sandu-Giuraniuc, A-L, Waymont, J M J, Murray, A, Cox, S R, de Rooij, S, Roseboom, T J & Wardlaw, J M 2021, 'Early life predictors of late life cerebral small vessel disease in four prospective cohort studies', Brain, vol. 144, no. 12, pp. 3769–3778. https://doi.org/10.1093/brain/awab3310006-8950ORCID: /0000-0002-5555-4129/work/107908297ORCID: /0000-0003-4915-4847/work/107908485ORCID: /0000-0002-5313-9845/work/107908795ORCID: /0000-0001-6688-7132/work/194700919https://hdl.handle.net/2164/18023Funding: Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006] and is currently supported by the Wellcome Trust [216767/Z/19/Z]. The MRI data collection was funded by the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” (STRADL) Reference 104036/Z/14/Z).” The LBC1936 is supported by Age UK [MR/M01311/1] (http://www.disconnectedmind.ed.ac.uk) and the Medical Research Council [G1001245/96099]. LBC1936 MRI brain imaging was supported by Medical Research Council (MRC) grants [G0701120], [G1001245], [MR/M013111/1] and [MR/R024065/1] and Row Fogo Charitable Trust (Grant No. BROD.FID3668413). Simpson’s Cohort was supported by the UK MRC and Chest Heart Stroke Scotland. JMJW received funding from TauRx Pharmaceuticals Ltd. EB received funding from the Sackler Foundation. JMW received funding from the UK Dementia Research Institute (DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK) and SVDs@Target, the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease, ref no. 16 CVD 05101086721engcerebral small vessel diseaseeducationchildhoodMRIepidemiologyR MedicineChief Scientist Office (CSO)CZD/16/6Wellcome Trust216767/Z/19/ZScottish Funding CouncilHR03006Medical Research Council (MRC)G0701120G1001245MR/M013111/1MR/R024065/1MR/M01311/1Other04036/Z/14/ZBROD.FID3668413Supplementary InformationSupplementary DataRJournal article10.1093/brain/awab331