Lecluze, EstelleRolland, Antoine D.Filis, PanagiotisEvrard, BertrandLeverrier-Penna, SabrinaBen Maamar, MillissiaCoiffec, IsabelleLavoué, VincentFowler , Paul A.Mazaud Guittot, SéverineJégou, BernardChalmel, Frédéric2021-05-142021-05-142020-05Lecluze, E, Rolland, A D, Filis, P, Evrard, B, Leverrier-Penna, S, Ben Maamar, M, Coiffec, I, Lavoué, V, Fowler , P A, Mazaud Guittot, S, Jégou, B & Chalmel, F 2020, 'Dynamics of the transcriptional landscape during human fetal testis and ovary development', Human Reproduction, vol. 35, no. 5, pp. 1099-1119. https://doi.org/10.1093/humrep/deaa0410268-1161ORCID: /0000-0002-4831-9075/work/79059748https://hdl.handle.net/2164/16470Acknowledgements We thank all members of the SEQanswers forums for helpful advice; Steven Salzberg and Cole Trapnell for continuous support with the ‘Tuxedo’ suite; and the UCSC Genome team members. Sequencing was performed by the GenomEast platform, a member of the ‘France Génomique’ consortium (ANR-10-INBS-0009). We thank Ms Linda Robertson, Ms Margaret Fraser, Ms Samantha Flannigan (University of Aberdeen) and the staff at Grampian NHS Pregnancy Counselling Service and all the staff of the Department of Obstetrics and Gynecology of the Rennes Sud Hospital for their expert assistance and help, and the participating women, without whom this study would not have been possible. The authors are grateful for Ms Gersende Lacombe and Mr Laurent Deleurme from the Biosit CytomeTri cytometry core facility of Rennes 1 University. Funding French National Institute of Health and Medical Research (Inserm); University of Rennes 1; French School of Public Health (EHESP); Swiss National Science Foundation [SNF n° CRS115_171007 to B.J.]; the French National Research Agency [ANR n° 16-CE14-0017-02 and n°18-CE14-0038-02 to F.C]; Medical Research Council [MR/L010011/1 to PAF]; European Community’s Seventh Framework Programme (FP7/2007–2013) [under grant agreement no 212885 to PAF]; European Union’s Horizon 2020 Research and Innovation Programme [under grant agreement no 825100 to P.A.F. and S.M.G.].212011752engSDG 3 - Good Health and Well-beinghuman gonad developmentfetal testisfetal ovarysex differentiationdisorders of sex developmenttranscriptional profilingnovel unannotated transcriptslong non-coding RNAsbulk RNA-sequencingproteomics informed by transcriptomicsLong non-coding RNAsSex differentiationFetal ovaryBulk RNA-sequencingHuman gonad developmentProteomics informed by transcriptomicsTranscriptional profilingDisorders of sex developmentFetal testisNovel unannotated transcriptsR MedicineObstetrics and GynaecologyReproductive MedicineMedical Research Council (MRC)MR/L010011/1European Commission212885825100Supplementary DataRJournal article10.1093/humrep/deaa041http://www.scopus.com/inward/record.url?scp=85085905497&partnerID=8YFLogxK