Kilgas, SusanSingh, Abhay NarayanPaillas, SalomeThen, Chee KinTorrecilla, IgnacioNicholson, JudithBrowning, LisaVendrell, IolandaKonietzny, RebeccaKessler, Benedikt M.Kiltie, Anne E.Ramadan, Kristijan2021-06-172021-06-172021-05-25Kilgas, S, Singh, A N, Paillas, S, Then, C K, Torrecilla, I, Nicholson, J, Browning, L, Vendrell, I, Konietzny, R, Kessler, B M, Kiltie, A E & Ramadan, K 2021, 'p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation', Cell Reports, vol. 35, no. 8, 109153. https://doi.org/10.1016/j.celrep.2021.1091532211-1247ORCID: /0000-0001-7208-2912/work/96970537https://hdl.handle.net/2164/16687Funding Information: This work was funded by Cancer Research UK (CRUK) program grant C5255/A23755 to A.E.K. Medical Research Council UK (MRC) program grant MC_PC 12001/1 (MC_UU_00001/1) and Breast Cancer Now (Grant No. 2019DecPR1406) to K.R. S.K. was supported by the MRC Oxford Institute of Radiation Oncology (OIRO) CRUK studentship. We thank Dr. Sovan Sarkar (Department of Oncology, University of Oxford) for generously providing DR-GFP U2OS cells. We thank Diogo Dias (Ludwig Cancer Research Institute, University of Oxford) for his technical advice on HR and SSA assays and assistance with the analysis. We thank Dr. Lisa Folkes and Alix Hampson for the high-performance liquid chromatography (HPLC) analysis of CB-5083 concentration in tissue extracts from CD-1 nude mice bearing subcutaneous RT112 tumors. We also thank the Oxford Radcliffe Biobank for providing us with human tissue sections.256020567engSDG 3 - Good Health and Well-beingbladder cancerCB-5083DNA damageDNA double-strand break repairhomologous recombinationionizing radiationIRMRE11p97single-strand annealingR MedicineGeneral Biochemistry,Genetics and Molecular BiologyCancer Research UKC5255/A23755Medical Research Council (MRC)MC_PC 12001/1OtherRJournal article10.1016/j.celrep.2021.109153http://www.scopus.com/inward/record.url?scp=85106522028&partnerID=8YFLogxK358