Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland

Green, ClaireStolicyn, AleksHarris, Mathew A.Shen, XueyiRomaniuk, LianaBarbu, Miruna C.Hawkins, Emma L.Wardlaw, Joanna M.Steele, J. DouglasWaiter, Gordon D.Sandu, Anca-LarisaCampbell, ArchiePorteous, David J.Seckl, Jonathan R.Lawrie, Stephen M.Reynolds, Rebecca M.Cavanagh, JonathanMcIntosh, Andrew M.Whalley, Heather C.2021-10-212021-10-212021-10-12Green, C, Stolicyn, A, Harris, M A, Shen, X, Romaniuk, L, Barbu, M C, Hawkins, E L, Wardlaw, J M, Steele, J D, Waiter, G D, Sandu, A-L, Campbell, A, Porteous, D J, Seckl, J R, Lawrie, S M, Reynolds, R M, Cavanagh, J, McIntosh, A M & Whalley, H C 2021, 'Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland', Translational Psychiatry, vol. 11, no. 1, 523. https://doi.org/10.1038/s41398-021-01644-92158-3188RIS: urn:92D790D742570CF5DBB51E1DBC6CE50BRIS: Green2021ORCID: /0000-0002-5555-4129/work/102132945ORCID: /0000-0002-5313-9845/work/102133223https://hdl.handle.net/2164/17374ACKNOWLEDGEMENTS We would like to thank all of the Generation Scotland participants for their contribution to this study. We also thank the research assistants, clinicians and technicians for their help in collecting the data. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006] and is currently supported by the Wellcome Trust [216767/Z/19/Z]. This study was also supported and funded by the Wellcome Trust Strategic Award ‘Stratifying Resilience and Depression Longitudinally’ (STRADL) (Reference 104036/Z/14/Z). We acknowledge the support of the British Heart Foundation (RE/18/5/34216). CG is supported by the Medical Research Council and the University of Edinburgh through the Precision Medicine Doctoral Training Programme. MCB is supported by a Guarantors of Brain Non-Clinical Post-Doctoral Fellowship. JMW is funded by the UK Dementia Research Institute which is funded by the UK Medical Research Council, Alzheimer’s Research UK and Alzheimer’s Society92223042engR MedicineChief Scientist Office (CSO)CZD/16/6OtherHR03006Wellcome Trust216767/Z/19/Z104036/Z/14/ZBritish Heart FoundationRE/18/5/34216Supplementary InformationRHair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation ScotlandJournal article10.1038/s41398-021-01644-9111