Melatonin treatment has consistent but only transient beneficial effects on sleep measures and pain in patients with severe chronic pain : the DREAM

Onyeakazi, UzunmaColumb, MalachyAdam, RosalindKanakarajan, SaravanakumarGalley, Helen2024-03-182024-03-182024-04Onyeakazi, U, Columb, M, Adam, R, Kanakarajan, S & Galley, H 2024, 'Melatonin treatment has consistent but only transient beneficial effects on sleep measures and pain in patients with severe chronic pain : the DREAM–CP randomised controlled trial', British Journal of Anaesthesia, vol. 132, no. 4, pp. 725-734. https://doi.org/10.1016/j.bja.2024.01.0120007-0912ORCID: /0000-0003-3082-6578/work/153542436ORCID: /0000-0002-8497-4982/work/153542808https://hdl.handle.net/2164/23040Acknowledgements We are very grateful to Flynn Pharma Ltd. for the provision of Circadin™ and placebo tablets for this trial. We acknowledge the members of the Trial Steering Group and the Data and Safety Monitoring Committee and the trial participants. Funding: British Journal of Anaesthesia/Royal College of Anaesthetists, grant reference WKR0-2017-0043.10726188engchronic painclinical trialcrossovermelatoninsleepR MedicineOtherWKR0-2017-0043RMelatonin treatment has consistent but only transient beneficial effects on sleep measures and pain in patients with severe chronic pain : the DREAM–CP randomised controlled trialJournal article10.1016/j.bja.2024.01.0121324