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Ching-YuWong, Tien-YinKhor, Chiea ChuenLi, HengtongSabanayagam, CharumathiPeters, AnnetteGieger, ChristianHattersley, Andrew TPedersen, Nancy LMagnusson, Patrik K EBoomsma, Dorret IWillemsen, Allegonda H MCupples, LAdriennevan Meurs, Joyce B JGhanbari, MohsenGordon-Larsen, PennyHuang, WeiKim, Young JinTabara, YasuharuWareham, Nicholas JLangenberg, ClaudiaZeggini, EleftheriaKuusisto, JohannaLaakso, MarkkuIngelsson, ErikAbecasis, GoncaloChambers, John CKooner, Jaspal Sde Vries, Paul SMorrison, Alanna CHazelhurst, ScottRamsay, MichèleNorth, Kari EDaviglus, MarthaKraft, PeterMartin, Nicholas GWhitfield, John BAbbas, ShahidSaleheen, DanishWalters, Robin GHolmes, Michael VBlack, CorriSmith, Blair HBaras, ArisJustice, Anne EBuring, Julie ERidker, Paul MChasman, Daniel IKooperberg, CharlesTamiya, GenYamamoto, Masayukivan Heel, David ATrembath, Richard CWei, Wei-QiJarvik, Gail PNamjou, BahramHayes, M GeoffreyRitchie, Marylyn DJousilahti, PekkaSalomaa, VeikkoHveem, KristianÅsvold, Bjørn OlavKubo, MichiakiKamatani, YoichiroOkada, YukinoriMurakami, YoshinoriKim, Bong-JoThorsteinsdottir, UnnurStefansson, KariZhang, JifengChen, YEugeneHo, Yuk-LamLynch, Julie ARader, Daniel JTsao, Philip SChang, Kyong-MiCho, KellyO'Donnell, Christopher JGaziano, John MWilson, Peter W FFrayling, Timothy MHirschhorn, Joel NKathiresan, SekarMohlke, Karen LSun, Yan VMorris, Andrew PBoehnke, MichaelBrown, Christopher DNatarajan, PradeepDeloukas, PanosWiller, Cristen JAssimes, Themistocles LPeloso, Gina M2023-02-232023-02-232022-12-27Kanoni, S, Graham, S E, Wang, Y, Surakka, I, Ramdas, S, Zhu, X, Clarke, S L, Bhatti, K F, Vedantam, S, Winkler, T W, Locke, A E, Marouli, E, Zajac, G J M, Wu, K-H H, Ntalla, I, Hui, Q, Klarin, D, Hilliard, A T, Wang, Z, Xue, C, Thorleifsson, G, Helgadottir, A, Gudbjartsson, D F, Holm, H, Olafsson, I, Hwang, M Y, Han, S, Akiyama, M, Sakaue, S, Terao, C, Kanai, M, Zhou, W, Brumpton, B M, Rasheed, H, Havulinna, A S, Veturi, Y, Pacheco, J A, Rosenthal, E A, Lingren, T, 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Grarup, N, Sever, P, Poulter, N, Chuang, L-M, Rotter, J I, Dantoft, T M, Karpe, F, Neville, M J, Timpson, N J, Cheng, C-Y, Wong, T-Y, Khor, C C, Li, H, Sabanayagam, C, Peters, A, Gieger, C, Hattersley, A T, Pedersen, N L, Magnusson, P K E, Boomsma, D I, Willemsen, A H M, Cupples, LA, van Meurs, J B J, Ghanbari, M, Gordon-Larsen, P, Huang, W, Kim, Y J, Tabara, Y, Wareham, N J, Langenberg, C, Zeggini, E, Kuusisto, J, Laakso, M, Ingelsson, E, Abecasis, G, Chambers, J C, Kooner, J S, de Vries, P S, Morrison, A C, Hazelhurst, S, Ramsay, M, North, K E, Daviglus, M, Kraft, P, Martin, N G, Whitfield, J B, Abbas, S, Saleheen, D, Walters, R G, Holmes, M V, Black, C, Smith, B H, Baras, A, Justice, A E, Buring, J E, Ridker, P M, Chasman, D I, Kooperberg, C, Tamiya, G, Yamamoto, M, van Heel, D A, Trembath, R C, Wei, W-Q, Jarvik, G P, Namjou, B, Hayes, M G, Ritchie, M D, Jousilahti, P, Salomaa, V, Hveem, K, Åsvold, B O, Kubo, M, Kamatani, Y, Okada, Y, Murakami, Y, Kim, B-J, Thorsteinsdottir, U, Stefansson, K, Zhang, J, Chen, YE, Ho, Y-L, Lynch, J A, Rader, D J, Tsao, P S, Chang, K-M, Cho, K, O'Donnell, C J, Gaziano, J M, Wilson, P W F, Frayling, T M, Hirschhorn, J N, Kathiresan, S, Mohlke, K L, Sun, Y V, Morris, A P, Boehnke, M, Brown, C D, Natarajan, P, Deloukas, P, Willer, C J, Assimes, T L & Peloso, G M 2022, 'Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis', Genome Biology, vol. 23, no. 1, 268. https://doi.org/10.1186/s13059-022-02837-11474-760XPubMedCentral: PMC9793579https://hdl.handle.net/2164/20148Funding GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007–2013 under grant agreement no. HEALTH-F2-2013–601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundation’s Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1–19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska Läkaresällskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Union’s Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file 32: Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.2235978engSDG 3 - Good Health and Well-beingHumansGenome-Wide Association StudyGenetic Predisposition to DiseaseSex CharacteristicsPhenotypeLipids/geneticsPolymorphism, Single NucleotideGenetic PleiotropycholesterolR MedicineSupplementary InformationRJournal article10.1186/s13059-022-02837-1231