Dambuza, Ivy MDrake, ThomasChapuis, AmbreZhou, XinCorreia, JoaoTaylor-Smith, LeanneLegrave, NathalieRasmussen, TimFisher, Matthew C.Bicanic, TihanaHarrison, Thomas SJaspars, MarcelMay, Robin CBrown, Gordon DYuecel, RaifMacCallum, Donna MBallou, Elizabeth2018-05-312018-05-312018-05-18Dambuza, I M, Drake, T, Chapuis, A, Zhou, X, Correia, J, Taylor-Smith, L, Legrave, N, Rasmussen, T, Fisher, M C, Bicanic, T, Harrison, T S, Jaspars, M, May, R C, Brown, G D, Yuecel, R, MacCallum, D M & Ballou, E 2018, 'The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis', PLoS Pathogens, vol. 14, no. 5, e1006978. https://doi.org/10.1371/journal.ppat.10069781553-7366ORCID: /0000-0003-4833-0378/work/47631087ORCID: /0000-0002-2426-6028/work/163664371http://hdl.handle.net/2164/10513We thank Prof Joseph Heitman and Prof Kirsten Nielsen for helpful discussions. We thank Dr Lukasz Kozubowski for feedback on the manuscript. We thank Prof Arturo Casadevall for the anti-capsule antibody 18B7. We are grateful to Drs Attila Bebes and Linda Duncan in the Iain Fraser Cytometry Centre (Aberdeen University), Delyth Reed, and Debbie Wilkinson, Lucinda Wight and Kevin MacKenzie in the Microscopy and Histology Core Facility (Aberdeen University) for their expert help with the cytometry and microscopy experiments. We are also grateful for the assistance of staff at the University of Aberdeen Medical Research Facility. Funding: ERB: This work was supported by the UK Biotechnology and Biological Research Council (http://www.bbsrc.ac.uk; BB/M014525/1). IMD: Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (wellcome.ac.uk; 097377). AC, DMM: UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (https://www.nc3rs.org.uk; NC/N002482/1). GDB: Wellcome Trust (wellcome.ac.uk; 102705). IMD, TD, AC, GDB, RY, and DMM: MRC Centre for Medical Mycology at the University of Aberdeen (https://www.mrc.ac.uk; www.abdn.ac.uk; MR/N006364/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.2813159504engCryptococcus neoformansTitan cellPathogenesisR MedicineBiotechnology and Biological Sciences Research Council (BBSRC)BB/M014525/1Wellcome Trust097377102705National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3R's)NC/N002482/1Medical Research Council (MRC)MR/N006364/1Supplementary DataRJournal article10.1371/journal.ppat.1006978145