Effect of perindopril or leucine on physical performance in older people with sarcopenia : the LACE randomized controlled trial

Achison, MarcusAdamson, SimonAkpan, AsangaedemAspray, TerryAvenell, AlisonBand, Margaret M.Bashir, TufailBurton, Louise A.Cvoro, VeraDonnan, Peter T.Duncan, Gordon W.George, JacobGordon, Adam L.Gregson, Celia L.Hapca, AdrianHenderson, EmilyHume, CherylJackson, Thomas A.Kemp, PaulKerr, SimonKilgour, AlixeLyell, VeronicaMasud, TahirMcKenzie, AndrewMcKenzie, EmmaPatel, HarnishPilvinyte, KristinaRoberts, Helen C.Rossios, ChristosSayer, Avan A.Smith, Karen T.Soiza, Roy L.Steves, Claire J.Struthers, Allan D.Sumukadas, DeepaTiwari, DivyaWhitney, JulieWitham, Miles D.LACE study group2022-06-162022-06-162022-04-01Achison, M, Adamson, S, Akpan, A, Aspray, T, Avenell, A, Band, M M, Bashir, T, Burton, L A, Cvoro, V, Donnan, P T, Duncan, G W, George, J, Gordon, A L, Gregson, C L, Hapca, A, Henderson, E, Hume, C, Jackson, T A, Kemp, P, Kerr, S, Kilgour, A, Lyell, V, Masud, T, McKenzie, A, McKenzie, E, Patel, H, Pilvinyte, K, Roberts, H C, Rossios, C, Sayer, A A, Smith, K T, Soiza, R L, Steves, C J, Struthers, A D, Sumukadas, D, Tiwari, D, Whitney, J, Witham, M D & LACE study group 2022, 'Effect of perindopril or leucine on physical performance in older people with sarcopenia : the LACE randomized controlled trial', Journal of Cachexia, Sarcopenia and Muscle, vol. 13, no. 2, pp. 858-871. https://doi.org/10.1002/jcsm.129342190-6009ORCID: /0000-0002-1397-4272/work/115134605ORCID: /0000-0003-4813-5628/work/167120437https://hdl.handle.net/2164/18718Acknowledgements: AAS, TA and MDW acknowledge support from the NIHR Newcastle Biomedical Research Centre. AA acknowledges support from the Health Services Research Unit which is core funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorate. The authors acknowledge support from the NIHR Ageing Clinical Research Network and the NHS Scotland Support for Science programme, The authors would also thank the efforts of all the research nurses and other ants to the trial, all the participants, and all the staff of the Tayside Clinical Trials Unit for their support of the trial. Funding: The LACE trial (project reference 13/53/03) is funded by the Efficacy and Mechanism Evaluation (EME) Programme, an MRC and NIHR partnership. The views expressed in this publication are those of the authors and not necessarily those of the MRC, NIHR or the Department of Health and Social Care.141075988engAngiotensin converting enzyme inhibitorLeucineSarcopeniaRandomised Controlled TriaMeta-Analysis as TopicHumansMaleTreatment OutcomePerindopril/therapeutic useSarcopenia/drug therapyHand Strength/physiologyFemaleAgedPhysical Functional PerformanceLeucine/therapeutic usePREVALENCESUPPLEMENTATIONINTERVENTIONSBIOELECTRICAL-IMPEDANCE ANALYSISSKELETAL-MUSCLE MASSADULTSELDERLY-PEOPLELOWER-EXTREMITY FUNCTIONRandomized controlled trialDOUBLE-BLINDASSOCIATIONR MedicinePhysiology (medical)Orthopedics and Sports MedicineMedical Research Council (MRC)13/53/03Chief Scientist Office (CSO)National Institute for Health Research (NIHR)Supplementary DataSupplementary InformationREffect of perindopril or leucine on physical performance in older people with sarcopenia : the LACE randomized controlled trialJournal article10.1002/jcsm.12934http://www.scopus.com/inward/record.url?scp=85128160996&partnerID=8YFLogxK132