Wiseman, Oliver J.Smith, DaronStarr, KathrynAucott, LornaHernández, Rodolfo AndrésThomas, RuthMacLennan, StevenClark, Charles TerryMacLennan, GraemeMcRae, DawnBell, VictoriaCotton, SeonaidhGall, ZaraTurney, BenMcClinton, Sam2025-05-232025-05-232025-04-22Wiseman, O J, Smith, D, Starr, K, Aucott, L, Hernández, R A, Thomas, R, MacLennan, S, Clark, C T, MacLennan, G, McRae, D, Bell, V, Cotton, S, Gall, Z, Turney, B & McClinton, S 2025, 'The PUrE Randomised Controlled Trial (RCT) 1 : Clinical and cost-effectiveness of Flexible Ureterorenoscopy and Extracorporeal Shockwave Lithotripsy for lower pole stones ≤10mm.', European Urology. https://doi.org/10.1016/j.eururo.2025.02.0020302-2838ORCID: /0000-0002-1039-5646/work/184793389ORCID: /0000-0002-2691-8421/work/184793441ORCID: /0000-0003-2619-8230/work/184793733ORCID: /0000-0002-8316-2616/work/184794136https://hdl.handle.net/2164/25499Special thanks must go to all of the PUrE trial participants. Thank you to all the staff at each of our recruiting centres for taking part in this trial. We thank our collaborators at the PUrE sites, and participating National Health Service (NHS) trusts: Ashford and St Peter's Hospitals NHS Foundation Trust, Belfast Health and Social Care Trust, Betsi Cadwaladr University Health Board, Blackpool Teaching Hospitals NHS Foundation Trust Bradford Teaching Hospitals NHS Foundation Trust, Cambridge University Hospitals NHS Foundation Trust, Dartford & Gravesham NHS Trust, East Kent Hospitals University NHS Foundation Trust,, East Lancashire Hospitals NHS Trust, East Sussex Healthcare NHS Trust, Epsom and St Helier University Hospitals NHS Trust, Gloucestershire Hospitals NHS Foundation Trust, Imperial College Healthcare NHS Trust, Kingston Hospital NHS Foundation Trust, Leeds Teaching Hospitals NHS Trust, Liverpool University Hospitals NHS Trust (formerly Royal Liverpool & Broadgreen University Hospitals NHS Trust), London North West University Healthcare NHS Trust, Manchester University NHS Foundation Trust (formerly Central Manchester University Hospitals NHS Foundation Trust, Manchester University NHS Foundation Trust (formerly University Hospital of South Manchester NHS Foundation Trust), Mid and South Essex NHS Foundation Trust (formerly Mid Essex Hospital Services NHS Trust), Mid Yorkshire Hospitals Trust, Newcastle Upon Tyne Hospitals NHS Foundation Trust NHS Fife, NHS Grampian, NHS Lothian, Norfolk and Norwich University Hospitals NHS Foundation Trust, North Bristol NHS Trust, Northern Care Alliance NHS Foundation Trust (formerly Salford Royal NHS Foundation Trust and formerly Pennine Acute Hospitals NHS Trust), Oxford University Hospitals NHS Foundation Trust, Rotherham NHS Foundation Trust, Royal Berkshire NHS Foundation Trust, Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, Royal Cornwall Hospital NHS Trust, Royal Devon University Healthcare NHS Foundation Trust (formerly Royal Devon and Exeter NHS Foundation Trust), Salisbury NHS Foundation Trust, Sheffield Teaching Hospitals Foundation Trust, South Tees Hospitals NHS Foundation Trust , South Tyneside and Sunderland NHS Foundation Trust (formerly City Hospitals Sunderland NHS Foundation Trust), Southport and Ormskirk Hospitals NHS Trust, St George's University Hospitals NHS Foundation Trust, St Helens and Knowsley Teaching Hospitals NHS Trust, Stockport NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust, University Hospitals Coventry and Warwickshire NHS Trust, University Hospitals Plymouth NHS Trust (formerly Plymouth Hospitals NHS Trust), University Hospitals Sussex NHS Foundation Trust (formerly Western Sussex NHS Foundation Trust), University Hospitals Sussex NHS Foundation Trust (formerly Brighton and Sussex University Hospitals NHS Trust), Wirral University Teaching Hospital NHS Foundation Trust. We thank all staff at the PUrE trial office based in the Centre for Healthcare Randomised Trials (CHaRT) within the Health Services Research Unit, University of Aberdeen. We thank all staff at the PUrE trial office based in the Centre for Healthcare Randomised Trials (CHaRT) within the Health Services Research Unit, University of Aberdeen. The trials managers and data coordinators who helped support the study: Katie Banister, Sarah Cameron, Karen Campbell, Tracey Davidson, Alison McDonald, Jess Wood (Trial Managers), Zoe Batham, Rebecca Bruce, Dianne Dejean and Sharon Wren (Data Co-ordinators) and the CHaRT programming team led by Mark Forrest and other staff within CHaRT/HSRU for their assistance with PUrE: Paul Manson, Information Scientist, Samantha Wileman, Quality Assurance Manager. We also thank the members of our Project Management Group, TSC and DMC for their expert support and guidance.413443engSubstantive connection via an eligible employment contractSDG 3 - Good Health and Well-beingrandomised controlled trialrenal stonelower pole stoneflexible ureterorenoscopyextracorporeal shockwave lithotripsyR Medicine (General)Supplementary DataDASSupplementary InformationR1Journal article10.1016/j.eururo.2025.02.002