Khanolkar, Rahul ChaitanyaZhang, Chual-Fatyan, FarahLawson, Linda GDepasquale, IvanMeredith, FionaMuller, FrankNicolson, MarianneDahal, Lekh NathAbu Eid, RashaRajpara, SanjayBarker, Robert NormanOrmerod, AnthonyWard, Frank James2022-01-072022-01-072022-01-05Khanolkar, R C, Zhang, C, al-Fatyan, F, Lawson, L G, Depasquale, I, Meredith, F, Muller, F, Nicolson, M, Dahal, L N, Abu Eid, R, Rajpara, S, Barker, R N, Ormerod, A & Ward, F J 2022, 'TGFb2 induces the soluble isoform of CTLA-4 – implications for CTLA-4 based checkpoint inhibitor antibodies in malignant melanoma', Frontiers in Immunology, vol. 12, 763877. https://doi.org/10.3389/fimmu.2021.7638771664-3224https://hdl.handle.net/2164/17798FUNDING This work was funded by the Chief Scientist’s office, Scotland grant no. ETM/280. Acknowledgments Microscopy was performed in the Microscopy and Histology Core Facility at the University of Aberdeen. Flow cytometry was performed in the Iain Fraser Cytometry Centre. We are very grateful to our lab manager Ms. Gill Moir for her assistance with this work and also to the many BSc/MSc project students who worked on this project. We are extremely grateful for all of the volunteer melanoma patient donors and healthy donors that supported this work. FA-F received an Elphinstone PhD scholarship funded by the School of Medicine, Medical Sciences & Nutrition at the University of Aberdeen.1415558408engSDG 3 - Good Health and Well-beingcheckpoint inhibitorCTLA-4 (cytotoxic T lymphocyte-associated antigen 4)sCTLA-4melanomaTGFb2T cellsR MedicineChief Scientist Office (CSO)ETM/280Supplementary DataRJournal article10.3389/fimmu.2021.76387712