Circulating and Tissue-resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function is Altered During Inflammation

Hegazy, Ahmed N.West, Nathaniel R.Stubbington, Michael J. T.Wendt, EmilySuijker, Kim I. M.Datsi, AngelikiThis, SebastienDanne, CamilleCampion, SuzanneDuncan, Sylvia HOwens, Benjamin M. J.Uhlig, Holm HMcMichael, AndrewOxford IBD Cohort InvestigatorsBergthaler, AndreasTeichmann, Sarah A.Keshav, SatishPowrie, Fiona2017-12-062017-12-062017-11Hegazy, A N, West, N R, Stubbington, M J T, Wendt, E, Suijker, K I M, Datsi, A, This, S, Danne, C, Campion, S, Duncan, S H, Owens, B M J, Uhlig, H H, McMichael, A, Oxford IBD Cohort Investigators, Bergthaler, A, Teichmann, S A, Keshav, S & Powrie, F 2017, 'Circulating and Tissue-resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function is Altered During Inflammation', Gastroenterology, vol. 153, no. 5, pp. 1320-1337. https://doi.org/10.1053/j.gastro.2017.07.0470016-5085ORCID: /0000-0002-4903-0978/work/76975497http://hdl.handle.net/2164/9689Grant support: ANH was supported by an EMBO long-term fellowship and a Marie Curiefellowship. NRW was supported by a CRI Irvington Post-doctoral Fellowship. BMJO was supported by an Oxford-UCB Pharma Postdoctoral Fellowship. MJTS and SAT were supported by ERC grant ThSWITCH and ThDEFINE (260507). SC and AM were supported by the Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (grant UM1-AI100645). The Rowett Institute of Nutrition and Health receives financial support from the Scottish Government Rural andEnvironmental Sciences and Analytical Services (SG-RESAS). Foundation Louis Jeantet, Wellcome Trust (Investigator award 095688/Z/11/Z), and ERC (ERC/HN/2013/21) supported FPand this project. HHU is supported by the Crohn’s & Colitis Foundation of America (CCFA), The Leona M. and Harry B. Helmsley Charitable Trust. SD receive financial support from the ScottishGovernment Rural and Environmental Sciences and Analytical Services (RESAS).182716690engSDG 3 - Good Health and Well-beingimmune regulationcytokinesTissue-resident Memory T cellsR MedicineEuropean Research Council260507ERC/HN/2013/21Wellcome Trust095688/Z/11/ZRCirculating and Tissue-resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function is Altered During InflammationJournal article10.1053/j.gastro.2017.07.0471535