Taljaard, MonicaWeijer, CharlesGrimshaw, Jeremy MAli, AdnanBrehaut, Jamie CCampbell, Marion KCarroll, KellyEdwards, SarahEldridge, SandraForrest, Christopher BGiraudeau, BrunoGoldstein, Cory EGraham, Ian DHemming, KarlaHey, Spencer PhillipsHorn, Austin RJairath, VipulKlassen, Terry PLondon, Alex JohnMarlin, SusanMarshall, John CMcIntyre, LauralynMcKenzie, Joanne ENicholls, Stuart GAlison Paprica, PZwarenstein, MerrickFergusson, Dean A2018-11-062018-11-062018-09-27Taljaard, M, Weijer, C, Grimshaw, J M, Ali, A, Brehaut, J C, Campbell, M K, Carroll, K, Edwards, S, Eldridge, S, Forrest, C B, Giraudeau, B, Goldstein, C E, Graham, I D, Hemming, K, Hey, S P, Horn, A R, Jairath, V, Klassen, T P, London, A J, Marlin, S, Marshall, J C, McIntyre, L, McKenzie, J E, Nicholls, S G, Alison Paprica, P, Zwarenstein, M & Fergusson, D A 2018, 'Developing a framework for the ethical design and conduct of pragmatic trials in healthcare : a mixed methods research protocol', Trials, vol. 19, 525. https://doi.org/10.1186/s13063-018-2895-x1745-6215PubMedCentral: PMC6161426ORCID: /0000-0001-5386-4097/work/91892203http://hdl.handle.net/2164/11399This work is supported by the Canadian Institutes of Health Research through the Project Grant competition (competitive, peer-reviewed), award number PJT-153045. Jeremy Grimshaw holds a Canada Research Chair in Health Knowledge Transfer and Uptake. Charles Weijer holds a Canada Research Chair in Bioethics. Sarah Edwards is funded by the UCL/UCLH Biomedical Research Centre (BRC). Vipul Jairath hold a personal Endowed Chair at Western University (John and Susan McDonald Endowed Chair). Joanne McKenzie is supported by an NHMRC Career Development Fellowship (1143429). The University of Aberdeen’s Health Services Research Unit is core-funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. Ian D Graham is a CIHR Foundation Grant recipient (FDN# 143237).926282engpragmatic randomized controlled trialsclinical trialsresearch ethicsinformed consentusual care interventionspatient-centered researchmixed methodsethics guidelinescomparative effectiveness researchlarge simple trialsR MedicineRJournal article10.1186/s13063-018-2895-x19