Srinivasan, MadhusudhanScheinost, Johanna C.Petela, Naomi J.Gligoris, Thomas G.Wissler, MariaOgushi, SugakoCollier, James E.Voulgaris, MenelaosKurze, AlexanderChan, Kok-LungHu, BinCostanzo, VincenzoNasmyth, Kim A.2020-04-132020-04-132018-05-31Srinivasan, M, Scheinost, J C, Petela, N J, Gligoris, T G, Wissler, M, Ogushi, S, Collier, J E, Voulgaris, M, Kurze, A, Chan, K-L, Hu, B, Costanzo, V & Nasmyth, K A 2018, 'The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms', Cell, vol. 173, no. 6, pp. 1508-1519.e18. https://doi.org/10.1016/j.cell.2018.04.0150092-8674ORCID: /0000-0001-6316-2830/work/50934078https://hdl.handle.net/2164/14050ACKNOWLEDGMENTS We are grateful to Katsuhiko Shirahige, Julian Blow, Tatsuro Takahashi, and Rob Klose for supplying antibodies and to Byung-Gil Lee and Jan Lo¨ we for sharing plasmids and protocols. We thank all members of the Nasmyth group for valuable discussions and technical assistance, in particular Jean Metson and Antonio Valde´ s Gutie´rrez. This work was funded by the Wellcome Trust (107935/Z/15/Z to K.A.N.), European Research Council (294401 to K.A.N.), Cancer Research UK (C573/A 12386 to K.A.N.), and Medical Research Council (MR/L018047/1 to K.A.N.). V.C. is funded by the Associazione Italiana per la Ricerca sul Cancro (AIRC) IG 17087, the ERC (614541), the Giovanni Armenise-Harvard foundation award, and Epigen Progetto Bandiera 4.7314975778engSDG 3 - Good Health and Well-beingloop extrusionsister chromatid cohesioncondensinSMCchromosome condensationR Medicine (General)Wellcome Trust107935/Z/15/ZEuropean Research Council294401614541Cancer Research UKC573/A 12386Medical Research Council (MRC)MR/L018047/1Supplementary DataR1Journal article10.1016/j.cell.2018.04.015http://europepmc.org/abstract/med/297548161736