Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat

Galley, Helen FMcCormick, BarryWilson, Kirsten L.Lowes, Damon A.Colvin, LesleyTorsney, Carole2017-10-132017-10-132017-11-01Galley, H F, McCormick, B, Wilson, K L, Lowes, D A, Colvin, L & Torsney, C 2017, 'Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat', Journal of Pineal Research, vol. 63, no. 4, e12444. https://doi.org/10.1111/jpi.124440742-3098ORCID: /0000-0002-9517-0074/work/37057087http://hdl.handle.net/2164/9435Acknowledgements Thank you to Professor Ahmet Hoke (Johns Hopkins, Baltimore, USA) for the gift of DRG cells; and to Professor Patrick M. Dougherty (MD Anderson Cancer Center, Texas, USA) for sharing his expertise in the rat model. Funding The study was funded by the Association of Anaesthetists of Great Britain and Ireland, the British Journal of Anaesthesia/Royal College of Anaesthetists and the Melville Trust.14961095engSDG 3 - Good Health and Well-beingNeuropathic painPaclitaxelmitochondriamelatoninchemotherapyoxidative stressantioxidantR Medicine (General)Supplementary DataR1Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the ratJournal article10.1111/jpi.12444634