Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection

Sutherland, Tara E.Rückerl, DominikLogan, NicolaDuncan, SheelaghWynn, Thomas A.Allen, Judith E.2024-03-282024-03-282018-11-30Sutherland, T E, Rückerl, D, Logan, N, Duncan, S, Wynn, T A & Allen, J E 2018, 'Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection', PLoS Pathogens, vol. 14, no. 11, : e1007423. https://doi.org/10.1371/journal.ppat.10074231553-7374Bibtex: 119e43416db34362ba8e0ea141f0b571ORCID: /0000-0001-9334-8206/work/120223466https://hdl.handle.net/2164/23136Acknowledgments The authors gratefully thank Stella Pearson, Brian Chan and Yvonne Harcus for excellent technical assistance, as well as Professor Rick M Maizels for the kind provision of Nippostrongylus brasiliensis and Dr. Martin Waterfall and Dr. Gareth Howell for flow cytometry support. The authors also thank Biological Services Facility staff at the University of Edinburgh and the University of Manchester, for help with animal husbandry. TES acknowledges the support of the Manchester Collaborative Centre for Inflammation Research, a joint venture between The University of Manchester and GlaxoSmithKline. This work was supported by: Medical Research Council UK, http://www.mrc.ac.uk/, grant numbers MR/K01207X/1 and MR/J001929/1 and Wellcome Trust, http://wellcome.ac.uk, grant number 106898/A/15/Z to JEA; Medical Research Foundation UK joint funding with Asthma UK, https://www.medicalresearchfoundation.org.uk and https://www.asthma.org.uk, grant number MRFAUK-2015-302 to TES. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.275712231engAnimalsIntercellular Signaling Peptides and Proteins/metabolismLectins/metabolismLung/immunologyMiceInbred BALB CInbred C57BLKnockoutNematode Infections/immunologyNippostrongylus/immunologyReceptorsCell Surface/deficiencySignal TransductionStrongylida Infections/immunologybeta-N-Acetylhexosaminidases/metabolismQH301 BiologyWellcome Trust106898/A/15/Z to JEAMedical Research Council (MRC)MR/K01207X/1MR/J001929/1Asthma UKMRFAUK-2015-302QH301Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infectionJournal article10.1371/journal.ppat.10074231411