Zeng, YanniNavarro, PauFernandez-Pujals, Ana MHall, Lynsey SClarke, Toni-KimThomson, Pippa ASmith, Blair HHocking, Lynne JPadmanabhan, SandoshHayward, CarolineMacIntyre, Donald JWray, Naomi RDeary, Ian JPorteous, David JHaley, Chris SMcIntosh, Andrew MMajor Depressive Disorder Working Group of the Psychiatric Genomics Consortium2017-08-302017-08-302017-02-15Zeng, Y, Navarro, P, Fernandez-Pujals, A M, Hall, L S, Clarke, T-K, Thomson, P A, Smith, B H, Hocking, L J, Padmanabhan, S, Hayward, C, MacIntyre, D J, Wray, N R, Deary, I J, Porteous, D J, Haley, C S, McIntosh, A M & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2017, 'A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorder', Biological Psychiatry, vol. 81, no. 4, pp. 336-346. https://doi.org/10.1016/j.biopsych.2016.04.0170006-3223PubMedCentral: PMC5262437http://hdl.handle.net/2164/9230This work was supported by the Wellcome Trust through a Strategic Award Reference No. 104036/Z/14/Z, the Dr. Mortimer and Theresa Sackler Foundation (T-KC and AMM), the Medical Research Council (MRC) to the Human Genetics Unit (PN and CSH), and the Biotechnology and Biological Sciences Research Council Grant No. BB/J004235/1 (PN and CSH). The Chief Scientist Office of the Scottish Government and the Scottish Funding Council provided core support for Generation Scotland (GS). GS: The Scottish Family Health Study (SFHS) was funded by a grant from the Scottish Government Health Department, Chief Scientist Office, No. CZD/16/6. This work was also supported by National Institutes of Health Grant No. UO1MH105630. We thank the families who took part in GS:SFHS, the general practitioners, and Scottish School of Primary Care for their help in recruiting them, and the whole GS team, which includes academic researchers, clinic staff, laboratory technicians, clerical workers, information technology staff, statisticians, and research managers. YZ thanks Mr. Ian White for the suggestion for analysis of polygenic score. AMF-P, LSH, BHS, LJH, SP, CH, and NRW report no biomedical financial interests or potential conflicts of interest. YZ received support from China Scholarship Council. PN and CSH received support from the MRC. T-KC and AMM received financial support for this work from the Dr. Mortimer and Theresa Sackler Foundation. PAT, IJD, DJP, and AMM are members of The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1). DJM is an NRS (National Health Service Research Scotland) Fellow, funded by the Chief Scientist Office. AMM previously received grant support from Pfizer, Lilly, and Janssen; those studies are not connected to the present investigation.112184323engDCCMDDNETRIN1Pathway analysisPolygenic risk scoreRegional heritabilityJournal ArticleQH426 GeneticsWellcome Trust104036/Z/14/ZMedical Research Council (MRC)Biotechnology and Biological Sciences Research Council (BBSRC)BB/J004235/1Chief Scientist Office (CSO)CZD/16/6Scottish Funding CouncilQH426Journal article10.1016/j.biopsych.2016.04.017814