Han, KimSingh, KomudiMeadows, Allison MSharma, RahulHassanzadeh, ShahinWu, JingGoss-Holmes, HaleyHuffstutler, Rebecca DTeague, Heather LMehta, Nehal NGriffin, Julian LTian, RongTraba, JavierSack, Michael N2023-10-032023-10-032023-09-19Han, K, Singh, K, Meadows, A M, Sharma, R, Hassanzadeh, S, Wu, J, Goss-Holmes, H, Huffstutler, R D, Teague, H L, Mehta, N N, Griffin, J L, Tian, R, Traba, J & Sack, M N 2023, 'Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects', Cell reports. Medicine, vol. 4, no. 9, pp. 101157. https://doi.org/10.1016/j.xcrm.2023.1011572666-3791PubMedCentral: PMC10518596ORCID: /0000-0003-1336-7744/work/144004086https://hdl.handle.net/2164/21816Acknowledgments We thank Myron Waclawiw of the NHLBI Biostatistics Branch for assistance with the clinical protocol design, Chromadex for supplying NR and matching placebo capsules for the in vivo study and NR powder for the cell culture studies, and an NIH Bench-to-Bedside award for supplemental funding. We additionally thank Dr. Nina Klimova, formerly of the NHLBI, and Dr. Yun-Wei A. Hsu for their support of the metabolomics analysis at the Northwest Metabolomics Research Center of the University of Washington (NIH grant 1S10OD021562-01). We thank and acknowledge the assistance of the NHLBI DNA Sequencing and Genomics Core in performing the RNA library sequencing and Dr. Pradeep Dagur in the NHLBI Flow Cytometry Core for performing the immunophenotyping. Trial registration was as follows: ClinicalTrials.gov: NCT01934660, NCT02812238, and NCT01143454 and NIH Clinical Center blood bank (ClinicalTrials.gov: NCT00001846). This work was supported by the NHLBI Division of Intramural Research (ZIA-HL005102 to M.N.S.), NIH Bench-to-Bedside award (HL-129510-04S1 to M.N.S. and R.T.) and the NIH Office of Dietary Supplements (J.T.), the Spanish Ministry of Science and Innovation (RYC2018-026050-I and PID2019-105665RA-I00 to J.T.), and the UK MRC (MR/P011705/2 and UKDRI-5002 to J.L.G.; MAP UK).237950006engSubstantive connection via an eligible employment contractHumansNAD/metabolismSequestosome-1 Protein/metabolismAntioxidants/metabolismNF-E2-Related Factor 2/geneticsOxidation-ReductionInflammation/drug therapyR MedicineSupplementary InformationRJournal article10.1016/j.xcrm.2023.10115749