Charmouh, AndersBocedi, GretaHartfield, Matthew2023-10-122023-10-122023-09Charmouh, A, Bocedi, G & Hartfield, M 2023, 'Inferring the distributions of fitness effects and proportions of strongly deleterious mutations', G3: Genes, Genomes, Genetics Mission, vol. 13, no. 9, jkad140. https://doi.org/10.1093/g3journal/jkad1402160-1836https://hdl.handle.net/2164/21900Open Access via the OUP Agreement Acknowledgments We thank Adam Eyre–Walker, Brian Charlesworth, Thomas Bataillon, Jane M. Reid, Roslyn Henry, and Max Tschol for many helpful ideas, comments, and suggestions. We also thank Nicolas Galtier for reading an earlier draft and providing many useful comments and much valuable feedback. Funding Anders P. Charmouh was supported by the University of Aberdeen. Greta Bocedi was supported by a Royal Society University Research Fellowship (UF160614). Matthew Hartfield is supported by a NERC Independent Research Fellowship (NE/R015686/1) and a UKRI Frontier Research Guarantee Grant (EP/X027570/1).11964696engDistribution of fitness effectsmutational effect inferencesite frequency spectrumWright-Fisher simulationstheoretical population geneticsPoisson random field theoryQH301 BiologyOtherUF160614Natural Environment Research Council (NERC)NE/R015686/1UK Research and Innovation (UKRI)EP/X027570/1Supplementary DataGithubQH301Journal article10.1093/g3journal/jkad140139