Symons, Rebecca A.Colella, FabioCollins, Fraser L.Rafipay, Alexandra J.Kania, KarolinaMcClure, Jessica J.White, NathanCunningham, IainAshraf, SadafHay, ElizabethMackenzie, Kevin S.Howard, Kenneth A.Riemen, Anna H. K.Manzo, AntonioClark, Susan M.Roelofs, Anke J.De Bari, Cosimo2022-04-132022-04-132022-02Symons, R A, Colella, F, Collins, F L, Rafipay, A J, Kania, K, McClure, J J, White, N, Cunningham, I, Ashraf, S, Hay, E, Mackenzie, K S, Howard, K A, Riemen, A H K, Manzo, A, Clark, S M, Roelofs, A J & De Bari, C 2022, 'Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis', Annals of the Rheumatic Diseases, vol. 81, no. 2, pp. 214-224. https://doi.org/10.1136/annrheumdis-2021-2208750003-4967ORCID: /0000-0002-1156-6873/work/111707768ORCID: /0000-0002-0041-5375/work/111708131Mendeley: dcf71690-7bf7-3edb-b6e4-90d3ed1b058eORCID: /0000-0002-2811-7919/work/127304773ORCID: /0009-0002-2404-5847/work/171980075https://hdl.handle.net/2164/18411ACKNOWLEDGEMENTS The authors thank staff at the University of Aberdeen’s Animal Facility, Microscopy and Histology Facility, qPCR Facility, and the Iain Fraser Cytometry Centre for their expert support. The authors also thank the NHS Grampian Biorepository for facilitating the collection of human tissue samples. Additionally, thanks is given to Denis Evseenko for critical review of the manuscript. Funding This work was supported by funding from the Medical Research Council (grants MR/L020211/1, MR/L022893/1), Versus Arthritis (formerly Arthritis Research UK, grants 20775, 19429, 21156, 20050, 19667, 20865, 21800), Tenovus Scotland (grant G13/14), and European Union’s Horizon 2020 research and innovation programme under Marie Sklodowska Curie (Grant 642414).1115004775engarthritisexperimentalrheumatoidfibroblastsinflammationCELLSGROWTHINHIBITIONEXPRESSIONSURVIVALCATENINYAP/TAZJOINTSIZEHumansSignal Transduction/physiologyFibroblasts/metabolismSynovial Membrane/metabolismCells, CulturedSnail Family Transcription Factors/metabolismYAP-Signaling Proteins/metabolismArthritis, Experimental/pathologyAnimalsInterleukin-6/metabolismMiceArthritis, Rheumatoid/metabolismR MedicineGeneral Biochemistry,Genetics and Molecular BiologyRheumatologyImmunology and AllergyImmunologyMedical Research Council (MRC)MR/L020211/1MR/L022893/1OtherG13/14Arthritis Research UK (ARUK)20775194292115620050196672086521800Supplementary InformationRJournal article10.1136/annrheumdis-2021-220875http://www.scopus.com/inward/record.url?scp=85123651848&partnerID=8YFLogxKhttps://www.mendeley.com/catalogue/dcf71690-7bf7-3edb-b6e4-90d3ed1b058e/812