Piedrafita, GabrielVarma, Sreejith J.Castro, CeciliaMessner, Christoph B.Szyrwiel, LukaszGriffin, Julian L.Ralser, Markus2022-01-182022-01-182021-12Piedrafita, G, Varma, S J, Castro, C, Messner, C B, Szyrwiel, L, Griffin, J L & Ralser, M 2021, 'Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure', PLoS Biology, vol. 19, no. 12, e3001468. https://doi.org/10.1371/journal.pbio.30014681544-9173ORCID: /0000-0003-1336-7744/work/106597843https://hdl.handle.net/2164/17914Acknowledgments We thank Markus Keller and members of the Ralser group for valuable discussions and critical comments, Olivier Languin-Cattoen and Maria Ouvarova for help in the nonenzymatic reaction screening, and Dr. Jae-Hun Jeoung (Humboldt University Berlin) for assistance in carrying out anaerobic reactions. This work was supported by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001134), the UK Medical Research Council (FC001134), and the Wellcome Trust (FC001134). MR received support from the Wellcome Trust (200829/Z/16/Z) and the Ministry of Education and Research (BMBF), as part of the National Research Node ‘Mass spectrometry in Systems Medicine (MSCoresys), under grant agreement 031L0220A. JLG was supported by the Medical Research Council UK (MR/P011705/1, MC_UP_A090_1006). GP acknowledges support by a Talento program fellowship from Comunidad de Madrid. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.232260825engSDG 3 - Good Health and Well-beingQH301 BiologyGeneral NeuroscienceGeneral Biochemistry,Genetics and Molecular BiologyGeneral Immunology and MicrobiologyGeneral Agricultural and Biological SciencesCancer Research UKFC001134Medical Research Council (MRC)MR/P011705/1Wellcome Trust200829/Z/16/ZQH301Journal article10.1371/journal.pbio.3001468http://www.scopus.com/inward/record.url?scp=85121916183&partnerID=8YFLogxK1912