Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

Lowes, D. A.Webster, N. R.Murphy, M. P.Galley, H. F.2017-11-022017-11-022013-03-01Lowes, D A, Webster, N R, Murphy, M P & Galley, H F 2013, 'Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis', British Journal of Anaesthesia, vol. 110, no. 3, pp. 472-480. https://doi.org/10.1093/bja/aes5770007-0912http://hdl.handle.net/2164/9559Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin, New Zealand, for the generous gifts of MitoE and MitoQ, without which this work would not have been possible.9294954engco-enzyme Q10interleukin-6interleukin-10melatoninsepsistocopherolR MedicineMedical Research Council (MRC)G0800149RAntioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsisJournal article10.1093/bja/aes577http://www.scopus.com/inward/record.url?scp=84874355329&partnerID=8YFLogxK1103