Relative abundance of the Prevotella genus within the human gut microbiota of elderly volunteers determines the inter-individual responses to dietary supplementation with wheat bran arabinoxylan-oligosaccharides

Chung, Wing Sun FaithWalker, AlanBosscher, DouwinaGarcia-Campayo, VicentaWagner, JosefParkhill, JulianDuncan, SylviaFlint, Harry J.2020-09-152020-09-152020-09-14Chung, W S F, Walker, A, Bosscher, D, Garcia-Campayo, V, Wagner, J, Parkhill, J, Duncan, S & Flint, H J 2020, 'Relative abundance of the Prevotella genus within the human gut microbiota of elderly volunteers determines the inter-individual responses to dietary supplementation with wheat bran arabinoxylan-oligosaccharides', BioMed Central Microbiology, vol. 20, 283. https://doi.org/10.1186/s12866-020-01968-41471-2180ORCID: /0000-0002-4903-0978/work/80462928ORCID: /0000-0001-5099-8495/work/80463415https://hdl.handle.net/2164/15131Acknowledgements: We would like to thank Donna Henderson for carrying out GC analysis. Thanks also to the Wellcome Sanger Institute’s core sequencing team for carrying out the Illumina MiSeq sequencing of 16S rRNA genes. The authors would also like to acknowledge the support of the Maxwell computer cluster funded by the University of Aberdeen. Funding: HJF, SHD and AWW receive financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (SG-RESAS) and this work was partly funded by the Biotechnology and Biological Sciences Research Council (BBSRC-CASE) which supported WSFC. Cargill, R&D Centre, Europe supplied the supplements used, helped to support WSFC industrial CASE studentship, including a 3 months training placement, agreed the study design and reviewed the final version of the manuscript. JW, JP and 16S rRNA gene sequencing costs were funded by the Wellcome Trust (grant number WT098051).142765545engSDG 3 - Good Health and Well-beinggut microbiotadiversitybacteroidesprevotellabifidobacteriawheatbran extractArabinoxylan oligosaccharides (AXOS)Short chain fatty acidsPropionateButyrateGut microbiotaBifidobacteriaDiversityWheatbran extractPrevotellaBacteroidesPOPULATIONRANDOMIZED CONTROLLED-TRIALFERMENTATIONDIVERSITYEXTRACTENTEROTYPESPROBIOTICSFOOD-FREQUENCY QUESTIONNAIRECEREAL ARABINOXYLANSNUTRITIONR MedicineMicrobiology (medical)MicrobiologyRural and Environmental Science and Analytical Services (RESAS)Biotechnology and Biological Sciences Research Council (BBSRC)Wellcome TrustWT098051RRelative abundance of the Prevotella genus within the human gut microbiota of elderly volunteers determines the inter-individual responses to dietary supplementation with wheat bran arabinoxylan-oligosaccharidesJournal article10.1186/s12866-020-01968-4http://www.scopus.com/inward/record.url?scp=85091053779&partnerID=8YFLogxK20