Ubah, Obinna CLake, Eric WGunaratne, Gihan SGallant, Joseph PFernie, MarieRobertson, Austin JMarchant, Jonathan SBold, Tyler DLanglois, Ryan AMatchett, William EThiede, Joshua MShi, KeYin, LuluMoeller, Nicholas HBanerjee, SurajitFerguson, LauraKovaleva, MarinaPorter, Andrew JAihara, HidekiLeBeau, Aaron MBarelle, Caroline J2021-12-232021-12-232021-12-16Ubah, O C, Lake, E W, Gunaratne, G S, Gallant, J P, Fernie, M, Robertson, A J, Marchant, J S, Bold, T D, Langlois, R A, Matchett, W E, Thiede, J M, Shi, K, Yin, L, Moeller, N H, Banerjee, S, Ferguson, L, Kovaleva, M, Porter, A J, Aihara, H, LeBeau, A M & Barelle, C J 2021, 'Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography', Nature Communications, vol. 12, no. 1, 7325. https://doi.org/10.1038/s41467-021-27611-y2041-1723https://hdl.handle.net/2164/17761Acknowledgements This work was supported by the Chief Scientist Office, Scottish Government, Grant COV/ABN/20/01 (Elasmogen, Ltd.), a 2018 Prostate Cancer Foundation Challenge Award (AML), a 2013 Prostate Cancer Foundation Young Investigator Award (AML), NCI R01s CA237272, CA233562, and CA245922 (AML). WEM was supported by the NIH T32 HL007741 and JMT by the NIH T32 AI055433. JSM was funded by NIGMS R01 GM088790. HA was funded by NIGMS R35 GM118047 and NCI P01 CA234228. X-ray diffraction data were collected at the Northeastern Collaborative Access Team beamlines, which are funded by the US National Institutes of Health (NIGMS P30 GM124165). The Pilatus 6M detector on 24-ID-C beamline is funded by a NIH-ORIP HEI grant (S10 RR029205). We thank the Marco Pravetoni lab for providing training and access to the OctetRED96e for BLI experiments.122980097engSDG 3 - Good Health and Well-beingAntibody fragment therapyProtein designR MedicineChief Scientist Office (CSO)COV/ABN/20/01Prostate Cancer UKCA245922CA233562NCI R01s CA237272Supplementary InformationRJournal article10.1038/s41467-021-27611-y121