Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue

McIlroy, GeorgeTammireddy, Seshu R.Maskrey, Benjamin H.Grant, LouiseDoherty, Mary K.Watson, David G.Delibegovic, MirelaWhitfield, Philip D.Mody, Nimesh2015-12-022015-12-022016-01-15McIlroy, G, Tammireddy, S R, Maskrey, B H, Grant, L, Doherty, M K, Watson, D G, Delibegovic, M, Whitfield, P D & Mody, N 2016, 'Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue', Biochemical Pharmacology, vol. 100, pp. 86-97. https://doi.org/10.1016/j.bcp.2015.11.0170006-2952ORCID: /0000-0003-4230-4355/work/102133123ORCID: /0000-0002-2215-7952/work/147568329ORCID: /0000-0001-6193-3152/work/160847613http://hdl.handle.net/2164/5265Acknowledgments This work was supported by the British Heart Foundation Intermediate Basic Research Fellowship FS/09/026/27398 to NM., the Biotechnology and Biological Sciences Research Council doctoral training grant awarded to GDM and the Wellcome Trust and the University of Aberdeen ISSF Fund to NM and LG and The Royal Society (of London) to NM. SRT, BHM, MKD and PDW gratefully acknowledge Highlands and Islands Enterprise, Scottish Funding Council and the European Regional Development Fund for financial support. The authors thank Tonya Martin (Johnson & Johnson, New Brunswick, NJ), and Urs Thurneer (Cilag AG, Schaffhausen, Switzerland) for the generous gift of Fenretinide to use completely without restriction or obligation. The authors thank Tonya Martin (Johnson & Johnson, New Brunswick, NJ), and Urs Thurneer (Cilag AG, Schaffhausen, Switzerland) for the generous gift of Fenretinide to use completely without restriction or obligation.123776676engSDG 3 - Good Health and Well-beingfenretinideretinoic acidadipocytesmetabolomicsdihydroceramidelipidomicsRM Therapeutics. PharmacologyBritish Heart FoundationFS/09/026/27398Wellcome TrustBiotechnology and Biological Sciences Research Council (BBSRC)Scottish Funding CouncilRMFenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissueJournal article10.1016/j.bcp.2015.11.017100