Wong, CharisGregory, JennaLiao, JingEgan, KierenVesterinen, Hanna M.Khan, Aimal AhmadAnwar, MaarijBeagan, CaitlinBrown, FraserCafferkey, JohnCardinali, AlessandraChiam, Jane YiChiang, ClaireCollins, VictoriaDormido, JoyceElliott, ElizabethFoley, PeterFoo, Yu ChengFulton-Humble, LilyGane, Angus B.Glasmacher, StellaHeffernan, ÁineJayaprakash, KiranJayasuriya, NimeshKaddouri, AminaKiernan, JamieLanglands, GavinLeighton, DanielleLiu, JiamingLyon, JamesMehta, Arpan R.Meng, AlyssaNguyen, ViviennePark, Kyu HyungQuigley, SuzanneRashid, YousufSalzinger, AndreaShiell, BethanySingh, AnkurSoane, TimThompson, AlexandraTomala, OlafWaldron, Fergal M.Selvaraj, Bhuvaneish T.Chataway, JeremySwingler, RobertConnick, PeterPal, SuvankarChandran, SiddharthanMacleod, Malcolm R.2022-07-142022-07-142022-04-22Wong, C, Gregory, J, Liao, J, Egan, K, Vesterinen, H M, Khan, A A, Anwar, M, Beagan, C, Brown, F, Cafferkey, J, Cardinali, A, Chiam, J Y, Chiang, C, Collins, V, Dormido, J, Elliott, E, Foley, P, Foo, Y C, Fulton-Humble, L, Gane, A B, Glasmacher, S, Heffernan, Á, Jayaprakash, K, Jayasuriya, N, Kaddouri, A, Kiernan, J, Langlands, G, Leighton, D, Liu, J, Lyon, J, Mehta, A R, Meng, A, Nguyen, V, Park, K H, Quigley, S, Rashid, Y, Salzinger, A, Shiell, B, Singh, A, Soane, T, Thompson, A, Tomala, O, Waldron, F M, Selvaraj, B T, Chataway, J, Swingler, R, Connick, P, Pal, S, Chandran, S & Macleod, M R 2022 'A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease' MedRxiv. https://doi.org/10.1101/2022.04.13.22273823ORCID: /0000-0003-3337-4079/work/112141039ORCID: /0000-0003-2622-0776/work/118591686https://hdl.handle.net/2164/18866Funding Statement For the purpose of open access, the authors have applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission. MND-SMART is funded by grants from MND Scotland, My Name'5 Doddie Foundation (DOD/14/15) and specific donations to the Euan MacDonald Centre. The Chandran lab is supported by the UK Dementia Research Institute, which receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society and Alzheimer's Research UK. E.E is a clinical academic fellow jointly funded by MND Scotland (MNDS) and the Chief Scientist Office (CSO) (217ARF R45951). A.R.M. was a Lady Edith Wolfson Clinical Fellow, jointly funded by the Medical Research Council (MRC) and the Motor Neurone Disease Association (MR/R001162/1). A.Salzinger is funded by Marie Sklodowska-Curie actions Innovative Training Network (ITN). B.T.S is funded by Rowling fellowship. Data availability Data are provided in supplementary material.997160engSDG 3 - Good Health and Well-beingmotor neuron diseaseamyotrophic lateral sclerosissystematic reviewevidence synthesisclinical trialsR MedicineRC0321 Neuroscience. Biological psychiatry. NeuropsychiatryMedical Research Council (MRC)MR/R001162/1Chief Scientist Office (CSO)217ARF R45951OtherDOD/14/15Supplementary DataRRC0321Preprint10.1101/2022.04.13.22273823