Greenan, CarolineMurphy, LynnYu, Ly-MeeKehoe, Patrick GCoulthard, ElizabethBath, PhilipStewart, RobertJones, RobCorbett, AnneThomas, AlanConnelly, PeterArrojo, FrankCanning, RachelWallach, SylviaHenderson, CatherineMcGuinness, BernadetteO'Sullivan, MikeHolmes, CliveKnapp, MartinBallard, ClivePassmore, PeterAFFECT InvestigatorsSoiza, Roy2018-03-212018-03-212016-07-18Greenan, C, Murphy, L, Yu, L-M, Kehoe, P G, Coulthard, E, Bath, P, Stewart, R, Jones, R, Corbett, A, Thomas, A, Connelly, P, Arrojo, F, Canning, R, Wallach, S, Henderson, C, McGuinness, B, O'Sullivan, M, Holmes, C, Knapp, M, Ballard, C, Passmore, P, AFFECT Investigators & Soiza, R 2016, 'A randomised controlled trial of calcium channel blockade (CCB) with Amlodipine For the treatment oF subcortical ischaEmic vasCular demenTia (AFFECT) : study protocol', Trials, vol. 17, 324. https://doi.org/10.1186/s13063-016-1449-31745-6215PubMedCentral: PMC4950108ORCID: /0000-0002-1397-4272/work/76608927http://hdl.handle.net/2164/10204The study is funded by the British Heart Foundation and the Alzheimer’s Society (grant number 184). We wish to acknowledge the support from the staff at the Northern Ireland Clinical Trials Unit; Paul Doherty, Nicola Goodfellow, Roisin Boyle, Mark Wilson, Annmarie Doran, Sam Cassidy and the Belfast Health and Social Care Trust; Margaret McFarland, Fiona Taylor.777192engActivities of Daily LivingAmlodipineBrain IschemiaCalcium Channel BlockersClinical ProtocolsCognitionDementia, VascularDouble-Blind MethodFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsQuality of LifeResearch DesignTime FactorsTreatment OutcomeUnited KingdomClinical Trial, Phase IIJournal ArticleMulticenter StudyRandomized Controlled TrialResearch Support, Non-U.S. Gov'tR MedicineBritish Heart FoundationRJournal article10.1186/s13063-016-1449-317