Tang, Walfred W CCastillo-Venzor, AracelyGruhn, Wolfram HKobayashi, ToshihiroPenfold, Christopher AMorgan, Michael DSun, DaweiIrie, NaokoSurani, M Azim2023-04-242023-04-242022-04-11Tang, W W C, Castillo-Venzor, A, Gruhn, W H, Kobayashi, T, Penfold, C A, Morgan, M D, Sun, D, Irie, N & Surani, M A 2022, 'Sequential enhancer state remodelling defines human germline competence and specification', Nature Cell Biology, vol. 24, no. 4, pp. 448-460. https://doi.org/10.1038/s41556-022-00878-z1465-7392PubMedCentral: PMC7612729ORCID: /0000-0003-0757-0711/work/133803885https://hdl.handle.net/2164/20542Acknowledgements M.A.S. was supported by Wellcome Investigator Awards in Science (209475/Z/17/Z and 096738/Z/11/Z), an MRC research grant (RG85305) and a BBSRC research grant (G103986). W.W.C.T. received a Croucher Postdoctoral Research Fellowship and was supported by the Isaac Newton Trust. A.C.-V. was supported by the Wellcome 4-Year PhD Programme in Stem Cell Biology and Medicine and the Cambridge Commonwealth European and International Trust (203831/Z/16/Z). W.H.G. was supported by a BBSRC research grant (G103986). T.K. and M.A.S. were supported by Butterfield Awards of Great Britain Sasakawa Foundation. T.K. was supported by the Astellas Foundation for Research on Metabolic Disorders. D.S. was supported by a Wellcome Trust PhD studentship (109146/Z/15/Z) and the Department of Pathology, University of Cambridge. N.I. was supported by an MRC research grant (RG85305). We thank R. Barker and X. He for providing human embryonic tissues, and C. Bradshaw for bioinformatic support. We also thank The Weizmann Institute of Science for the WIS2 hESC line and the Genomics Core Facility of CRUK Cambridge Institute for sequencing services, and R. Alberio and members of the Surani lab for insightful comments and critical reading of the manuscript.1347486705engAnimalsCell Differentiation/geneticsEmbryonic Development/geneticsEndodermGastrulationGene Expression Regulation, DevelopmentalGerm Cells/metabolismHumansMammalsQH426 GeneticsWellcome Trust209475/Z/17/Z096738/Z/11/Z203831/Z/16/ZMedical Research Council (MRC)RG85305Biotechnology and Biological Sciences Research Council (BBSRC)G103986Supplementary DataQH426Journal article10.1038/s41556-022-00878-zhttps://www.repository.cam.ac.uk/handle/1810/334690244