Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors

Al-Wahaibi, Lamya H.Mohammed, Anber F.Abdel Rahman, Fatema El Zahraa S.Abdelrahman, Mostafa H.Gu, XuyuanTrembleau, LaurentYoussif, Bahaa G.M.2023-06-202023-06-202023-05-31Al-Wahaibi, L H, Mohammed, A F, Abdel Rahman, F E Z S, Abdelrahman, M H, Gu, X, Trembleau, L & Youssif, B G M 2023, 'Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR WT/ EGFR T790M inhibitors', Journal of enzyme inhibition and medicinal chemistry, vol. 38, no. 1, 2218602. https://doi.org/10.1080/14756366.2023.22186021475-6374ORCID: /0000-0001-6376-9077/work/137297622https://hdl.handle.net/2164/20935Funding This work was funded by Princess Nourah Bint Abdulrahman University Researchers Supporting Project Number [PNURSP2023R3], Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.12536510engADMEantiproliferativeapoptosisEGFRIndolemutationresistanceRS Pharmacy and materia medicaPharmacologyDrug DiscoverySupplementary InformationRSDesign, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitorsJournal article10.1080/14756366.2023.2218602http://www.scopus.com/inward/record.url?scp=85160634957&partnerID=8YFLogxK381