Melis, VZabke, CStamer, KMagbagbeolu, MSchwab, KMarshall, P.Weh, R. W.Bachmann, SDeiana, SMoreau, P HDavidson, KHarrington, K ARickard, J EHorsley, DGarman, RMazurkiewicz, MNiewiadomska, GWischik, C MHarrington, C RRiedel, GTheuring, F.2015-05-282015-05-282015-06Melis, V, Zabke, C, Stamer, K, Magbagbeolu, M, Schwab, K, Marshall, P, Weh, R W, Bachmann, S, Deiana, S, Moreau, P H, Davidson, K, Harrington, K A, Rickard, J E, Horsley, D, Garman, R, Mazurkiewicz, M, Niewiadomska, G, Wischik, C M, Harrington, C R, Riedel, G & Theuring, F 2015, 'Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration', Cellular and Molecular Life Sciences, vol. 72, no. 11, pp. 2199-2222. https://doi.org/10.1007/s00018-014-1804-z1420-682XORCID: /0000-0001-7063-7136/work/96652489ORCID: /0000-0003-2250-3920/work/47672898http://hdl.handle.net/2164/4567Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Acknowledgments From the Berlin Laboratory, we thank Ingo Voigt for performing the injections of the two constructs into the oocytes, Bettina Seelhorst for her extensive technical assistance, Anna Thoma for taking specific care of the animals, and John Horn, Charite Core Facility for electron microscopy for performing expert analyses in ultra-cryosections with immunogold technique. Expert comments on the manuscript from Silke Frahm-Barske (Berlin) are also acknowledged. Special thanks to Bob Switzer at NeuroScience Associates Inc. for embedding, sectioning and staining mouse brains. This work was funded by TauRx Therapeutics, Singapore. C.R.H. and C.M.W. declare that they are officers in TauRx Therapeutics Ltd.2411254039engSDG 3 - Good Health and Well-beingTau proteintransgenic miceP301Ltruncated cDNA Tau296-390motor impairmentspatial cognitionQH301 BiologyQH301Journal article10.1007/s00018-014-1804-z7211