Westbrook, Jules ACairns, David APeng, JianheSpeirs, ValerieHanby, Andrew MHolen, IngunnWood, Steven LOttewell, Penelope DMarshall, HelenBanks, Rosamonde ESelby, Peter JColeman, Robert EBrown, Janet E2018-07-202018-07-202016-04Westbrook, J A, Cairns, D A, Peng, J, Speirs, V, Hanby, A M, Holen, I, Wood, S L, Ottewell, P D, Marshall, H, Banks, R E, Selby, P J, Coleman, R E & Brown, J E 2016, 'CAPG and GIPC1 : Breast Cancer Biomarkers for Bone Metastasis Development and Treatment', Journal of the National Cancer Institute, vol. 108, no. 4. https://doi.org/10.1093/jnci/djv3600027-8874PubMedCentral: PMC4808632ORCID: /0000-0002-0602-4666/work/72631208http://hdl.handle.net/2164/10776This work was supported by Cancer Research UK (grant number: C18605/A 10048) through a Clinician Scientist Fellowship (to JEB). DAC was supported by a UK Medical Research Council Career Development Fellowship (G0802416). The authors are solely responsible for the design of the study; the collection, analysis and interpretation of the data; the writing of the manuscript; and the decision to submit the manuscript for publication. All authors read and approved the final article. The authors are especially grateful to Professor Joan Massagué for kindly providing the bone- and lung-homing variants of MDA-MB-231 cells used in this study. We also particularly thank the AZURE trial patients and investigators, Mr. Mike Shires and the staff of the Sheffield and Leeds Experimental Cancer Medicine Centres for infrastructure support5068034engSDG 3 - Good Health and Well-beingAdaptor Proteins, Signal TransducingBiomarkers, TumorBone Density Conservation AgentsBone NeoplasmsBreast NeoplasmsCell Line, TumorDiphosphonatesDisease ProgressionFemaleHumansImidazolesImmunohistochemistryKaplan-Meier EstimateLung NeoplasmsMicrofilament ProteinsMolecular Targeted TherapyNuclear ProteinsOdds RatioPredictive Value of TestsProportional Hazards ModelsRandomized Controlled Trials as TopicReproducibility of ResultsEditorialResearch Support, Non-U.S. Gov'tR MedicineCancer Research UKC18605/A 10048Medical Research Council (MRC)G0802416RJournal article10.1093/jnci/djv3601084