Buchanan, HeatherMackay, MurrayPalmer, KerriTothová, KarolínaKatsur, MiroslavaPlatt, BettinaKoss, David J.2020-07-142020-07-142020-08Buchanan, H, Mackay, M, Palmer, K, Tothová, K, Katsur, M, Platt, B & Koss, D J 2020, 'Synaptic Loss, ER Stress and Neuro-inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease', Molecular Neurobiology, vol. 57, pp. 3258-3272. https://doi.org/10.1007/s12035-020-01950-10893-7648SCOPUS: 85086107840ORCID: /0000-0002-7852-0749/work/76976857https://hdl.handle.net/2164/14702Acknowledgements We would like to deeply thank all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the Alzheimer’s Society and the Medical Research Council, and sourced from the MRC London Neurodegenerative Diseases Brain Bank, the Manchester Brain Bank, the South West Dementia Brain Bank (SWDBB), the Newcastle Brain Tissue Resource and the Oxford Brain Bank. The Newcastle Brain Tissue Resource and Oxford Brain Bank are also supported by the National Institute for Health Research (NIHR) Units. The South West Dementia Brain Bank (SWDBB) receives additional support from BRACE (Bristol Research into Alzheimer’s and Care of the Elderly). Use of human tissue for this work was approved by Brains for Dementia Research from London – City and East NRES committee 08/H0704/128+5. The work presented here was funded by Alzheimer’s Research UK (Grant refs: ARUK-PPG2014A-21, ARUK-NSG2015-1, ARUK-NCG2017A-3 awarded to DK and BP). HB was supported by an Alzheimer’s Society Doctoral Training Centre grant (grant ref: 228) to BP. MK’s participation in the project was funded by ARUK Scotland Network pump priming award to DK and BP. Antibodies CP13 and PHF1 were generously provided by Prof. Peter Davies. TOC1 antibodies were a gift from Nicholas Kanaan at Michigan State University (originally created by Lester Binder at Northwestern University). Funding The work presented here was funded by Alzheimer’s Research UK (Grant refs: ARUK-PPG2014A-21, ARUK-NSG2015-1, ARUK-NCG2017A-3 awarded to DK and BP). HB was supported by an Alzheimer’s Society Doctoral Training Centre grant (grant ref:228) to BP. MK’s participation in the project was funded by ARUK Scotland Network pump priming award to DK and BP.153454984engSDG 3 - Good Health and Well-beingAlzheimer's diseasetauamyloidSynapseunfolded protein responseneuroinflammationNeuro-inflammationHUMAN BRAINPHOSPHORYLATIONTRANSGENIC MOUSETauAMYLOID-BETA-PROTEINENDOPLASMIC-RETICULUM STRESSMODELUnfolded protein responseCOGNITIVE DECLINEUNFOLDED PROTEIN RESPONSEEIF2-ALPHAEXPRESSIONAmyloid-betaAlzheimer’s diseaseAmyloid-βRC0321 Neuroscience. Biological psychiatry. NeuropsychiatryNeurologyCellular and Molecular NeuroscienceAlzheimers Research UKARUK-PPG2014A-21ARUK-NSG2015-1ARUK-NCG2017A-3Supplementary DataRC0321Journal article10.1007/s12035-020-01950-1http://www.scopus.com/inward/record.url?scp=85086107840&partnerID=8YFLogxKhttps://rdcu.be/b4Khu57