Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial

Dawson, JesseRobertson, MicheleDickie, David AlexanderBath, PhillipForbes, KirstenQuinn, TerenceBroomfield, Niall M.Dani, KrishnaDoney, AlexHouston, GraemeLees, Kennedy R.Muir, Keith W.Struthers, AllanWalters, MatthewBarber, MarkBhalla, AjayCameron, AlanDyker, AlexanderGuyler, PaulHassan, AhamadKearney, Mark T.Keegan, BreffniLakshmanan, SekaranMacleod, Mary JoanRandall, MarcShaw, LouiseSubramanian, GaneshWerring, DavidMcConnachie, Alex2023-02-202023-02-202023-03-01Dawson, J, Robertson, M, Dickie, D A, Bath, P, Forbes, K, Quinn, T, Broomfield, N M, Dani, K, Doney, A, Houston, G, Lees, K R, Muir, K W, Struthers, A, Walters, M, Barber, M, Bhalla, A, Cameron, A, Dyker, A, Guyler, P, Hassan, A, Kearney, M T, Keegan, B, Lakshmanan, S, Macleod, M J, Randall, M, Shaw, L, Subramanian, G, Werring, D & McConnachie, A 2023, 'Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial', EClinicalMedicine, vol. 57, 101863. https://doi.org/10.1016/j.eclinm.2023.1018632589-5370RIS: urn:F198F7588192254F912BD60537171CE7ORCID: /0000-0003-2115-8184/work/129409185https://hdl.handle.net/2164/20110Acknowledgments This work was supported by the Stroke Association and British Heart Foundation [grant number TSA BHF 2013/01]. The work of Dr David Dickie and Dr Terry Quinn is funded by the Stroke Association. We would like to thank Christine McAlpine, Ruth Graham, Glasgow Royal Infirmary, UK; Lauren Pearce, Royal United Hospital, UK; Caroline Fornolles, Louise Tate, Frances Justin, Luton and Dunstable University Hospital, UK; Dean Waugh, Leeds Teaching Hospitals NHS Trust, UK; Donal Concannon, Altnagelvin Hospital, UK; Sharon Tysoe, Nina Francia, Nisha Menon, Raji Prabakaran, Southend University Hospital, UK; Amy Ashton, Caroline Watchurst, Marilena Marinescu, Sabaa Obarey, Scheherazade Feerick, University College London NHS Foundation Trust, UK; and Janice Irvine, Sandra Williams, and German Guzman Gutierrez, Aberdeen Royal Infirmary, UK; Caroline Fox and Joanne Topliffe, Broomfield Hospital, Essex, UK.10325953engStrokeAllopurinolHypertensionWhite matter hyperintensitiesR MedicineBritish Heart FoundationTSA BHF 2013/01Supplementary DataRXanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trialJournal article10.1016/j.eclinm.2023.10186357