Magloire, VincentSavtchenko, Leonid P.Jensen, Thomas P.Sylantyev, SergyiKopach, OlgaCole, NicholasTyurikova, OlgaKullmann, Dimitri M.Walker, Matthew C.Marvin, Jonathan S.Looger, Loren L.Hasseman, Jeremy P.Kolb, IlyaPavlov, IvanRusakov, Dmitri A.2023-05-032023-05-032023-04-10Magloire, V, Savtchenko, L P, Jensen, T P, Sylantyev, S, Kopach, O, Cole, N, Tyurikova, O, Kullmann, D M, Walker, M C, Marvin, J S, Looger, L L, Hasseman, J P, Kolb, I, Pavlov, I & Rusakov, D A 2023, 'Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network', Current Biology, vol. 33, no. 7, pp. 1249-1264.e7. https://doi.org/10.1016/j.cub.2023.02.0510960-9822ORCID: /0000-0002-1358-0601/work/134240338https://hdl.handle.net/2164/20621Funding Information: This work was supported by Wellcome Principal Fellowship (212251/Z/18/Z and 212285/Z/18/Z), Wellcome Collaborative Award (UNS120639 - 223131/Z/21/Z), Epilepsy Research UK (F1901), MRC (MR/W019752/1, MR/V013556/1, and MR/V034758/1), NC3Rs (NC/X001067/1), and ERC Advanced Grant (323113). Optimization and parallelization of ARACHNE algorithms for extended neural network simulations was provided by AMC Bridge (Waltham, MA) and web security by Cyber Curio (Berkhamsted, UK). L.P.S. and D.A.R. narrated the study. I.P. and V.M. designed and carried out electrophysiological and optogenetic studies. N.C. O.K. and T.P.J. designed, carried out, and analyzed iGABASnFR2 imaging experiments. S.S. carried out sniffer-patch experiments. O.T. carried out control-probing K+ imaging tests. L.P.S. designed and carried out network modeling studies and data analyses. J.S.M. L.L.L. J.P.H. and I.K. supplied optical GABA sensors and related protocols. The development of iGABASnFR2 was conducted under the aegis of the HHMI Janelia GENIE Project at Janelia Research Campus. D.M.K. and M.C.W. designed optogenetic experiments. D.A.R. designed selected experiments and simulations, carried out selected analyses, and wrote the manuscript draft, with contributions from V.M. L.P.S. and all other authors. The authors declare no competing interests. We support inclusive, diverse, and equitable conduct of research. Publisher Copyright: © 2023 The Author(s)13554790engbrain rhythmsepilepsyextracellular GABAGABA uptakeGAT-1iGABASnFR2spiking neural networkstonic GABA conductancevolume transmissionR MedicineGeneral NeuroscienceGeneral Biochemistry,Genetics and Molecular BiologyGeneral Agricultural and Biological SciencesWellcome Trust212251/Z/18/Z212285/Z/18/ZUNS120639 - 223131/Z/21/ZMedical Research Council (MRC)MR/W019752/1MR/V013556/1MR/V034758/1National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3R's)NC/X001067/1European Research Council323113Supplementary InformationRJournal article10.1016/j.cub.2023.02.051http://www.scopus.com/inward/record.url?scp=85151495947&partnerID=8YFLogxK337