Mitchell, Joanne L.Little, GemmaBye, Alexander P.Gaspar, Renato S.Unsworth, Amanda J.Kriek, NelineSage, TanyaStainer, AlexanderSangowawa, IbidayoMorrow, Gael B.Bastos, Ricardo N.Shapiro, SusanDesborough, Michael J.R.Curry, NicolaGibbins, Jonathan M.Whyte, Claire S.Mutch, Nicola J.Jones, Christopher I.2023-08-182023-08-182023-07Mitchell, J L, Little, G, Bye, A P, Gaspar, R S, Unsworth, A J, Kriek, N, Sage, T, Stainer, A, Sangowawa, I, Morrow, G B, Bastos, R N, Shapiro, S, Desborough, M J R, Curry, N, Gibbins, J M, Whyte, C S, Mutch, N J & Jones, C I 2023, 'Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability', Research and Practice in Thrombosis and Haemostasis, vol. 7, no. 5, 100200. https://doi.org/10.1016/j.rpth.2023.100200ORCID: /0000-0001-9299-6754/work/140898542ORCID: /0000-0001-8127-6102/work/140899326ORCID: /0000-0002-7452-0813/work/169538879https://hdl.handle.net/2164/21498Funding Information: The authors thank Dr Ana Raquel Pereira from Oxford Nanoimaging for help with the direct STORM imaging and analysis. The authors also thank the microscopy core facilities at the University of Reading and the University of Aberdeen for excellent advice and use of the microscopes and facilities. The authors further thank Christopher Deane from the Oxford Haemophilia and Thrombosis centre for assistance with patient blood collection and Dr Nicholas Michael from the University of Reading Mass Spectrometry facility for performing mass spectrometry. This study was supported by the University of Reading School of Biological Sciences Seed funding grant (J.L.M.) and a grant from the British Heart Foundation (PG/16/36/31967, to C.I.J. and J.M.G.) and by the University of Aberdeen Development Trust (N.J.M. and J.L.M.). S.S. receives funding support from the Medical Research Council (MR/T024054/1). Informed consent was given by all normal health blood donors on this study with ethical approval from the University of Reading Research Ethics Committee (UREC 20/20). Informed consent was given by all patients recruited in this study with ethical approval by the Oxford Biobank (ORB Research Tissue Bank (RTB) ethics approval 09/H0606/5+5). J.L.M. conceptualized and designed the research, performed experiments, analyzed and interpreted data, and wrote the manuscript. G.L. performed the experiments and analyzed data. A.P.B. performed experiments and analyzed the data. R.S.G. performed experiments and analyzed data. A.J.U. performed experiments, analyzed data, and wrote the manuscript. N.K. performed experiments and analyzed data. T.S. performed experiments. A.S. performed experiments and analyzed data. I.S. performed experiments and analyzed data. G.B.M. performed experiments and analyzed data. R.N.B. performed experiments and analyzed data. S.S. provided patient samples and clinical advice. N.C. provided patient samples and clinical advice. J.M.G. interpreted data, obtained ethical approval for controls, and wrote the manuscript. C.S.W. interpreted data and wrote the manuscript. M.J.R.D. provided patient samples, obtained patient ethical approval, and provided clinical advice. N.J.M. designed the research, interpreted data, and wrote the manuscript. C.I.J. designed the research, interpreted data, obtained patient ethical approval, and wrote the manuscript. R.N.B is Director of Business Development at Oxford Nanoimaging.155239586engclot retractionfactor XIIIfibrinogenfibrinolysisplateletplatelet activationR MedicineHematologyRJournal article10.1016/j.rpth.2023.100200https://www.scopus.com/pages/publications/85166003061