In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence

Ross, Zoe K.Alsayegh, SakinahZhao, YixinMcPherson, StevenMunro, Carol A.Lorenz, Alexander2025-12-102025-12Ross, Z K, Alsayegh, S, Zhao, Y, McPherson, S, Munro, C A & Lorenz, A 2025, 'In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence', Microbiological Research, vol. 301, 128322. https://doi.org/10.1016/j.micres.2025.1283220944-5013RIS: urn:2D239CE725DE932BD6E3B0D76356DC5FORCID: /0000-0003-0761-1755/work/190474466https://hdl.handle.net/2164/26525Open Access via the Elsevier agreement115072401engcaspofunginantimicrobial resistanceevolutioncell wallstress responseQR MicrobiologyQRIn vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulenceJournal article10.1016/j.micres.2025.128322