Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis

Minter, Beverley ELowes, Damon AWebster, Nigel RGalley, Helen F2020-03-042020-03-042020-02-26Minter, B E, Lowes, D A, Webster, N R & Galley, H F 2020, 'Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis', Antioxidants, vol. 9, no. 3, 195. https://doi.org/10.3390/antiox90301952076-3921https://hdl.handle.net/2164/13776Funding: This research was funded by The British Journal of Anaesthesia/Royal College of Anaesthetists (PhD studentship to Beverley Minter). Acknowledgments: We are very grateful to Professor M.P. Murphy, MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge, UK for the generous gift of MitoVitE used in all the experiments, without which this work would not have been possible.14767932engsepsisMitoVitEantioxidantmitochondriagene expressioncytokinesmRNAVITAMIN-EACTIVATIONFACTOR-KAPPA-BINTERLEUKIN-6DAMAGEIN-VITROTARGETED ANTIOXIDANTSEPTIC SHOCKLIPOPOLYSACCHARIDEORGAN DYSFUNCTIONCytokinesAntioxidantGene expressionMitochondriaSepsisR MedicineMolecular BiologyBiochemistryPhysiologyClinical BiochemistryCell BiologySupplementary DataRDifferential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking SepsisJournal article10.3390/antiox9030195http://www.scopus.com/inward/record.url?scp=85085705334&partnerID=8YFLogxK93