Meakin, Paul J.Jalicy, Susan M.Montagut, GemmaAllsop, David J. P.Cavellini, Daniella L.Irvine, Stuart W.McGinley, ChristopherLiddell, Mary K.McNeilly, Alison D.Parmionova, KarolinaLiu, Yu-RuBailey, Charlotte L. S.Dale, J. KimHeisler, Lora K.McCrimmon, Rory J.Ashford, Michael L. J.2018-01-082018-01-082018-01-08Meakin, P J, Jalicy, S M, Montagut, G, Allsop, D J P, Cavellini, D L, Irvine, S W, McGinley, C, Liddell, M K, McNeilly, A D, Parmionova, K, Liu, Y-R, Bailey, C L S, Dale, J K, Heisler, L K, McCrimmon, R J & Ashford, M L J 2018, 'Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice', Scientific Reports, vol. 8, 55. https://doi.org/10.1038/s41598-017-18388-62045-2322RIS: urn:9CD211481D5C8D9FD71BBEDF0705D41ERIS: Meakin2018http://hdl.handle.net/2164/9874We thank AstraZeneca for providing AZ-4217, Mark Smith (Imperial College, London) and Yuchio Yanagawa (Gunma University, Maebashi) for VGlut2-GFP and GAD67-GFP tissue, respectively. This work was funded by Medical Research Council (MR/K003291/1), Diabetes UK (12/0004458), British Heart Foundation (PG/15/44/31574) and Biotechnology and Biological Sciences Research Council CASE (with AstraZeneca) award (BB/I015663/1) to MLJA and by a grant to LKH from the Wellcome Trust (WT098012).2893850engSDG 3 - Good Health and Well-beinghypothalamusobesityR MedicineMedical Research Council (MRC)MR/K003291/1British Heart FoundationPG/15/44/31574Biotechnology and Biological Sciences Research Council (BBSRC)BB/I015663/1Wellcome TrustWT098012RJournal article10.1038/s41598-017-18388-68