Schleich, FlorenceLarenas-Linnemann, DésiréeAltraja, AlanPérez de Llano, LuisKostikas, KonstantinosSadatsafavi, MohsenBourdin, ArnaudPleasants, Roy AltonHew, MarkChen, WenjiaJiménez-Maldonado, LibardoCouillard, SimonSuppli Ulrik, CharlotteBulkhi, Adeeb A.Tsai, Ming-JuChristoff, George C.Papadopoulos, Nikolaos G.Pfeffer, Paul E.Ryan, DermotBergeron, CelineAl-Ahmad, Mona S.Dorscheid, Delbert R.Wang, EileenBlakey, John D.Cochrane, BelindaPeters, Matthew J.Popov, Todor A.Torres-Duque, Carlos A.Hansen, SusannePuggioni, FrancescaFletton, KirstySalameh, LailaMiddleton, Peter G.Márcio Pitrez, PauloKook Rhee, ChinDenton, EveChapman, Kenneth R.Lehtimäki, LauriMurray, Ruth B.Sheu, Chau-ChyunJackson, David J.Al-Lehebi, RiyadSiyue Koh, MarikoMahboub, BassamArdusso, Ledit R.F.Gogali, AthenaCanonica, Giorgio WalterKuna, PiotrTownend, JohnCosio, Borja G.Patel, Pujan HGoh, Yun Yi CelineCsoma, ZsuzsannaUpham, John WFonseca, João A.Gibson, Peter G.Jenkins, ChristineBrusselle, GuyChèvremont, AnneCôté, AndréanneCelis-Preciado, Carlos AndresSolarte, IvanPorsbjerg, Celeste M.Sverrild, AsgerKauppi, PaulaLoukides, SteliosMakris, Michael P.Papaioannou, Andriana I.Heffler, EnricoChan, Jeffrey Shi KaiJoo, HyonsooHeaney, Liam GCheng, Wei-HanLugogo, NjiraWechsler, Michael ELoureiro, Cláudia ChavesRodríguez-Cáceres, BellanidNagano, TatsuyaWang, ZhixiaoWang, Hao-ChienMáspero, JorgeSaldarini, FernandoStok, Ana MaríaYañez, AnahiBardin, Philip GBosnic-Anticevich, Sinthia ZNavaratnam, VidyaBhutani, MohitLougheed, M. DianeMelenka, LyleBakakos, PetrosExarchos, Konstantinos P.Ladias, Aggelos A.Lúdvíksdóttir, DóraIwanaga, TakashiContreras Contreras, Elvia AngelicaLehmann, SverreFerreira, José AlbertoGall, RebeccaFu, Pin-KueiPerng, Diahn WarngHoyte, FlaviaKatial, RohitBjörnsdóttir, UnnurTaillé, CamilleTaube, ChristianCushen, BredaBulathsinhala, LakminiBjermer, LeifPrice, David B.the ISAR STAR Working Group2025-06-052025-06-052025-07Schleich, F, Larenas-Linnemann, D, Altraja, A, Pérez de Llano, L, Kostikas, K, Sadatsafavi, M, Bourdin, A, Pleasants, R A, Hew, M, Chen, W, Jiménez-Maldonado, L, Couillard, S, Suppli Ulrik, C, Bulkhi, A A, Tsai, M-J, Christoff, G C, Papadopoulos, N G, Pfeffer, P E, Ryan, D, Bergeron, C, Al-Ahmad, M S, Dorscheid, D R, Wang, E, Blakey, J D, Cochrane, B, Peters, M J, Popov, T A, Torres-Duque, C A, Hansen, S, Puggioni, F, Fletton, K, Salameh, L, Middleton, P G, Márcio Pitrez, P, Kook Rhee, C, Denton, E, Chapman, K R, Lehtimäki, L, Murray, R B, Sheu, C-C, Jackson, D J, Al-Lehebi, R, Siyue Koh, M, Mahboub, B, Ardusso, L R F, Gogali, A, Canonica, G W, Kuna, P, Townend, J, Cosio, B G, Patel, P H, Goh, Y Y C, Csoma, Z, Upham, J W, Fonseca, J A, Gibson, P G, Jenkins, C, Brusselle, G, Chèvremont, A, Côté, A, Celis-Preciado, C A, Solarte, I, Porsbjerg, C M, Sverrild, A, Kauppi, P, Loukides, S, Makris, M P, Papaioannou, A I, Heffler, E, Chan, J S K, Joo, H, Heaney, L G, Cheng, W-H, Lugogo, N, Wechsler, M E, Loureiro, C C, Rodríguez-Cáceres, B, Nagano, T, Wang, Z, Wang, H-C, Máspero, J, Saldarini, F, Stok, A M, Yañez, A, Bardin, P G, Bosnic-Anticevich, S Z, Navaratnam, V, Bhutani, M, Lougheed, M D, Melenka, L, Bakakos, P, Exarchos, K P, Ladias, A A, Lúdvíksdóttir, D, Iwanaga, T, Contreras Contreras, E A, Lehmann, S, Ferreira, J A, Gall, R, Fu, P-K, Perng, D W, Hoyte, F, Katial, R, Björnsdóttir, U, Taillé, C, Taube, C, Cushen, B, Bulathsinhala, L, Bjermer, L, Price, D B & the ISAR STAR Working Group 2025, 'Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)', World Allergy Organization Journal, vol. 18, no. 7, 101066. https://doi.org/10.1016/j.waojou.2025.1010661939-4551RIS: urn:2F762A3AA267CB3EF177C2398C150E11https://hdl.handle.net/2164/25538The authors would also like to thank Ms Karen Hosking of the Optimum Patient Care Global for the data analytics and Ms Pui Yee Lai (MA) of the Observational and Pragmatic Research Institute (OPRI), Singapore, for editorial and formatting assistance which supported the development of this publication. Finally, a big thank you to our International Severe Asthma Registry collaborators (see online Supplement).29826699engBECBlood eosinophil countFractional exhaled nitric oxideFeNOIgEImmunoglobulin EIntermittentLong-termR Medicine (General)Supplementary DataDASR1Journal article10.1016/j.waojou.2025.101066187