Martínez-López, MaríaIborra, SalvadorConde-Garrosa, RuthMastrangelo, AnnalauraDanne, CamilleMann, Elizabeth RReid, Delyth MGaboriau-Routhiau, ValérieChaparro, MariaLorenzo, María PMinnerup, LaraSaz-Leal, PaulaSlack, EmmaKemp, BenjaminGisbert, Javier PDzionek, AndrzejRobinson, Matthew JRupérez, Francisco JCerf-Bensussan, NadineBrown, Gordon DBernardo, DavidLeibundGut-Landmann, SaloméSancho, David2019-03-042019-03-042019-02-19Martínez-López, M, Iborra, S, Conde-Garrosa, R, Mastrangelo, A, Danne, C, Mann, E R, Reid, D M, Gaboriau-Routhiau, V, Chaparro, M, Lorenzo, M P, Minnerup, L, Saz-Leal, P, Slack, E, Kemp, B, Gisbert, J P, Dzionek, A, Robinson, M J, Rupérez, F J, Cerf-Bensussan, N, Brown, G D, Bernardo, D, LeibundGut-Landmann, S & Sancho, D 2019, 'Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity', Immunity, vol. 50, no. 2, pp. 446-461. https://doi.org/10.1016/j.immuni.2018.12.0201074-7613Mendeley: 1b14beec-5376-3901-88d6-c6207279d6d9http://hdl.handle.net/2164/11998We are grateful to members of the D.S. laboratory and Dr. E. Fernández-Malavé for discussions and critical reading of the manuscript. We appreciate the support of A. Tomás-Loba, G. Sabio, P. Martín, A. Tsilingiri, A.R. Ramiro, C.L. Abram, C.A. Lowell, J.M. García-Lobo, M. Molina, and M.C. Rodríguez for providing reagents and support. We thank the staff at the Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) facilities for technical support. M.M.-L. received a Formación de Personal Universitario (FPU) fellowship (AP2010-5935) from the Spanish Ministerio de Educación. S.I. is funded by grant SAF2015-74561-JIN from the Spanish Ministerio de Ciencia, Innovación, y Universidades (MCIU) and Fondos Europeos de Desarrollo Regional (FEDER). G.D.B and D.M.R. are supported by the Wellcome Trust and the MRC Centre for Medical Mycology at the University of Aberdeen. S.L.L. is supported by the Swiss National Science Foundation (PP00P3_150758). Work in the D.S. laboratory is funded by the CNIC and grant SAF2016-79040-R from MCIU, the Agencia Estatal de Investigación, and FEDER; B2017/BMD-3733 Immunothercan-CM from Comunidad de Madrid; RD16/0015/0018-REEM from FIS-Instituto de Salud Carlos III, MCIU, and FEDER; the Acteria Foundation; the Constantes y Vitales prize (Atresmedia); La Marató de TV3 Foundation (201723); the European Commission (635122-PROCROP H2020), and the European Research Council (ERC-2016-Consolidator Grant 725091). The CNIC is supported by the MCIU and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).154400993engSDG 3 - Good Health and Well-beingintestinal barrierdendritic cellT lymphocyteinnate lymphoid cellsMinkleSyk kinaseIL-17IL-22antimicrobial defensegut microbiota translocationliver inflammationlipid metabolismMincleIGAC-TYPE LECTINCOMMENSAL BACTERIAROR-GAMMA-TPEYERS-PATCHESINDUCTIONINNATE LYMPHOID-CELLSADAPTIVE IMMUNITYT(H)17 CELLSDIFFERENTIATIONR MedicineInfectious DiseasesImmunology and AllergyImmunologyRJournal article10.1016/j.immuni.2018.12.020http://www.scopus.com/inward/record.url?scp=85061393496&partnerID=8YFLogxKhttp://www.mendeley.com/research/microbiota-sensing-minclesyk-axis-dendritic-cells-regulates-interleukin17-22-production-promotes-int-1502