Mayer, Claus-Dieterde La Giclais, Soizick MagonAlsehly, FozanHoppler, Stefan2020-05-142020-05-142020-05Mayer, C-D, de La Giclais, S M, Alsehly, F & Hoppler, S 2020, 'Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies', Genes, vol. 11, no. 5, 538. https://doi.org/10.3390/genes110505382073-4425https://hdl.handle.net/2164/14315Funding: CM acknowledges funding from the Scottish Government: Rural & Environment Science & Analytical Services. (RESAS). SH is a Royal Society/Leverhulme Trust Senior Research Fellow (SRF\R1\191017) and acknowledges research funding from the Biotechnology and Biological Sciences Research Council (BB/S018190/1, BB/M001695/1). Author Contributions: C.-D.M. and S.H. had conceived and supervised this project; C.-D.M. curated the data and carried out some analysis; S.M.L.G., carried out most of the analysis; F.A. wrote an original draft together with Stefan Hoppler. All authors have read and agreed to the published version of the manuscript. Supplementary Materials: The following are available online at www.mdpi.com/2073-4425/11/5/538/s1: Figure S1: Principal Component Analysis of selected studies, Figure S2: Principal Component Analysis of de-selected study, Table S1: Transcriptomics Data (Correlation Coefficients) Table S1A: Transcript correlation between eight selected genes (TCF7, LEF1, TCF7L1, TCF7L2, AXIN2, DKK1, FZD7, LGR5); Table S1B: The TCF7-correlated transcriptome; Table S1C: The LEF1correlated transcriptome; Table S1D: The TCF7L1-correlated transcriptome; Table S1E: The TCF7L2-correlated transcriptome; Table S1F: The AXIN2-correlated transcriptome; Table S1G: The DKK1-correlated transcriptome; Table S1H: The FZD7-correlated transcriptome; Table S1I: The LGR5-correlated transcriptome; Table S1J: Differences in LEF/TCF-correlated transcriptomes; Table S1K: Differences between AXIN2- and LEF/TCF-correlated transcriptomes, Table S2: Correlated Transcriptome in normal and tumor tissue, Table S3: Comparison of LEF/TCF-correlated transcriptomes, Table S4: Differences between AXIN1- and LEF/TCF-correlated transcriptomes.232729659engSDG 3 - Good Health and Well-beingWntcolorectal cancerTCFLEFtranscriptomeHUMAN COLONTARGETSTEM-CELLSPROTEINCYCLIN D1BETA-CATENINNEGATIVE REGULATOROVEREXPRESSIONGENESIGNALING PATHWAYColorectal cancerTranscriptomeQH426 GeneticsR Medicine (General)Genetics(clinical)GeneticsBiotechnology and Biological Sciences Research Council (BBSRC)BB/M001695/1BB/S018190/1Rural and Environmental Science and Analytical Services (RESAS)Supplementary DataQH426R1Journal article10.3390/genes11050538http://www.scopus.com/inward/record.url?scp=85084626943&partnerID=8YFLogxKhttp://www.mdpi.com/2073-4425/11/5/538/s1115