Abraham, SabuScarcia, MargheritaBagshaw, Richard DMcMahon, KathrynGrant, GaryHarvey, TraceyYeo, MaggieEsteves, Filomena O GThygesen, Helene HJones, Pamela FSpeirs, ValerieHanby, Andrew MSelby, Peter JLorger, MihaelaDear, T NeilPawson, TonyMarshall, Christopher JMavria, Georgia2018-07-272018-07-272015-07-01Abraham, S, Scarcia, M, Bagshaw, R D, McMahon, K, Grant, G, Harvey, T, Yeo, M, Esteves, F O G, Thygesen, H H, Jones, P F, Speirs, V, Hanby, A M, Selby, P J, Lorger, M, Dear, T N, Pawson, T, Marshall, C J & Mavria, G 2015, 'A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis', Nature Communications, vol. 6, 7286. https://doi.org/10.1038/ncomms82862041-1723PubMedCentral: PMC4507007ORCID: /0000-0002-0602-4666/work/72631319http://hdl.handle.net/2164/10817We thank Hironori Katoh for EGFP DOCK4; Vijay Yajnik for flag-tagged DOCK4 and deletion mutants; Martin Schwartz for the DOCK9 expression construct; Len Stephens for RhoG expression construct; Jean-François Côté for GST–ELMO. We thank Janine Erler for advice on CA-IX staining and Kiran Kulkarni for discussions on DOCK9; Demelza Bird and Kris Wronski for the tumour experiments; Ben Woodman and staff at St James’ Biological Services for ES microinjections and animal husbandry; Biological Services Unit, ICR, for animal husbandry; Mike Shires for optimization of DOCK4 IHC; Anne Sanford and Rebecca Horsfall for technical assistance; Sean Lawler and other colleagues for commenting on the manuscript. The work was funded through project grant from Cancer Research UK (C107/A7631) awarded to C.J.M. and G.M.; project grant from Yorkshire Cancer Research (L357) and pilot grant from Breast Cancer Campaign (2012MaySP047) awarded to G.M. T.P. was supported by grants from the Ontario Research Fund GL2 program and CIHR (MOP-6849); and R.D.B. was supported by a CIHR fellowship. C.J.M. is a Gibb Life Fellow of Cancer Research UK.144849380engSDG 3 - Good Health and Well-beingAnimalsCytoskeletonGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsHuman Umbilical Vein Endothelial CellsHumansMice, Inbred C57BLMice, KnockoutNeovascularization, PathologicNeovascularization, PhysiologicPseudopodiaVascular Endothelial Growth Factor Acdc42 GTP-Binding Proteinrho GTP-Binding ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tR MedicineCancer Research UKSupplementary DataRJournal article10.1038/ncomms82866