Landberg, RikardManach, ClaudineKerckhof, Frederiek-MaartenMinihane, Anne-MarieSaleh, Rasha Noureldin MDe Roos, BaukjeTomas-Barberan, FranciscoMorand, ChristineVan de Wiele, Tom2019-11-082019-11-082019-11Landberg, R, Manach, C, Kerckhof, F-M, Minihane, A-M, Saleh, R N M, De Roos, B, Tomas-Barberan, F, Morand, C & Van de Wiele, T 2019, 'Future prospects for dissecting inter-individual variability in the absorption, distribution and elimination of plant bioactives of relevance for cardiometabolic endpoints', European Journal of Nutrition, vol. 58, no. Suppl 2, pp. 21-36. https://doi.org/10.1007/s00394-019-02095-11436-6207ORCID: /0000-0002-2750-3914/work/161795905https://hdl.handle.net/2164/13240Acknowledgements This article is based upon work from COST Action FA1403 POSITIVe (Interindividual variation in response to consumption of plant food bioactives and determinants involved) supported by COST (European Cooperation in Science and Technology; www.cost.eu). The authors also acknowledge all the partners involved in working group 1 of the COST Action POSITIVe. Author contributions RL, CM and TVdW conceived and drafted the manuscript. FMK, A-MM, RNMS and FT-B added specific sections and all the authors contributed with critical intellectual input, read and revised the final draft. Funding COST (European Cooperation in Science and Technology) Action FA1403 (2014–2018).162270937engPlant bioactive compoundsCardiometabolicInter-individual variationpersonalized nutritionPersonalized nutritionRISKBIOAVAILABILITYCOMT GENOTYPEDEMETHYLASEFLAVANONESO-METHYLTRANSFERASE GENOTYPEVASCULAR FUNCTIONASSOCIATIONCONSUMPTIONCYP1A2 GENOTYPER MedicineRJournal item10.1007/s00394-019-02095-158