Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression

Zeng, YanniNavarro, PauXia, CharleyAmador, CarmenFernandez-Pujals, Ana MThomson, Pippa ACampbell, ArchieNagy, RekaClarke, Toni-KimHafferty, Jonathan DSmith, Blair HHocking, Lynne JPadmanabhan, SandoshHayward, CarolineMacIntyre, Donald JPorteous, David JHaley, Chris SMcIntosh, Andrew M2017-08-292017-08-292016-12Zeng, Y, Navarro, P, Xia, C, Amador, C, Fernandez-Pujals, A M, Thomson, P A, Campbell, A, Nagy, R, Clarke, T-K, Hafferty, J D, Smith, B H, Hocking, L J, Padmanabhan, S, Hayward, C, MacIntyre, D J, Porteous, D J, Haley, C S & McIntosh, A M 2016, 'Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression', EBioMedicine, vol. 14, pp. 161-167. https://doi.org/10.1016/j.ebiom.2016.11.0032352-3964PubMedCentral: PMC5161419http://hdl.handle.net/2164/9220This work is supported by the Wellcome Trust through a Strategic Award, reference 104036/Z/14/Z. GS:SFHS was funded by a grant from the Scottish Government Health Department, Chief Scientist Office, number CZD/16/6. The authors acknowledge with gratitude the financial support received for this work from the Dr. Mortimer and Theresa Sackler Foundation. PAT, DJP and AMM are members of The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1). Funding from the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC) is gratefully acknowledged by PN and CSH (BB/J004235/1). DJM is an NRS Fellow, funded by the CSO.7531894engDepressionDepressive Disorder, MajorEnvironmentFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenotypeHumansMaleModels, StatisticalPhenotypePolymorphism, Single NucleotideRiskSelf ReportJournal ArticleR MedicineWellcome Trust104036/Z/14/ZChief Scientist Office (CSO)CZD/16/6Medical Research Council (MRC)MR/K026992/1Biotechnology and Biological Sciences Research Council (BBSRC)BB/J004235/1RShared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared DepressionJournal article10.1016/j.ebiom.2016.11.00314