Frangou, SophiaShirali, MasoudAdams, Mark JHoward, David MGibson, JudeHall, Lynsey SSmith, Blair HPadmanabhan, SandoshMurray, Alison DPorteous, David JHaley, Chris SDeary, Ian JClarke, Toni-KimMcIntosh, Andrew M2019-05-142019-05-142019-06Frangou, S, Shirali, M, Adams, M J, Howard, D M, Gibson, J, Hall, L S, Smith, B H, Padmanabhan, S, Murray, A D, Porteous, D J, Haley, C S, Deary, I J, Clarke, T-K & McIntosh, A M 2019, 'Insulin resistance : Genetic associations with depression and cognition in population based cohorts', Experimental Neurology, vol. 316, pp. 20-26. https://doi.org/10.1016/j.expneurol.2019.04.0010014-4886Mendeley: 493e021a-690e-334b-b9ae-03c1b5c1b4c4ORCID: /0000-0003-4915-4847/work/76976592http://hdl.handle.net/2164/12268We are grateful to the families who took part in GS:SFHS, general practitioners and the Scottish School of Primary Care for their help in recruitment, and the whole GS:SFHS team that includes academic researchers, clinic staff, laboratory technicians, clerical workers, IT staff, statisticians and research managers. The research reported here, and the genotyping of GS:SFHS samples was funded by the Wellcome Trust, (Wellcome Trust Strategic Award ‘STratifying Resilience and Depression Longitudinally’ (STRADL) Reference 104036/Z/14/Z) and by the Medical Research Council. SF acknowledges support from the National Institute of Mental Health, USA (R01MH113619; R01MH116147) and the consortium for Psychopathology and Allostatic load across the Life Span (PALS; https://www.pals-network.org) AMM acknowledges the financial support received from the Dr. Mortimer and Theresa Sackler Foundation. IJD and AMM are members of The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1). Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). Funding from the Biotechnology and Biological Sciences Research Council and Medical Research Council is gratefully acknowledged.7406109engInsulin resistanceMendelian randomizationPolygenic risk scoresGenetic associationDepressionCognitionR Medicine (General)Wellcome Trust104036/Z/14/ZSupplementary DataR1Journal article10.1016/j.expneurol.2019.04.001http://www.mendeley.com/research/insulin-resistance-genetic-associations-depression-cognition-population-based-cohorts316