Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function.

Asowata, Evans O.Romoli, SimoneSargeant, RebeccaTan, Jennifer Y.Hoffmann, ScottHuang, Margaret M.Mahbubani, Krishnaa TKrause, Fynn N.Jachimowicz, DanielAgren, RasmusKoulman, AlbertJenkins, Benjamin JMusial, BarbaraGriffin, JulesSoderberg, MagnusLing, StephanieHansen, Pernille B.L.Saeb-Parsy, KouroshWoollard, Kevin J.2024-07-162024-07-162024-07-01Asowata, E O, Romoli, S, Sargeant, R, Tan, J Y, Hoffmann, S, Huang, M M, Mahbubani, K T, Krause, F N, Jachimowicz, D, Agren, R, Koulman, A, Jenkins, B J, Musial, B, Griffin, J, Soderberg, M, Ling, S, Hansen, P B L, Saeb-Parsy, K & Woollard, K J 2024, 'Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function.', Kidney International, vol. 106, no. 1, pp. 85-97. https://doi.org/10.1016/j.kint.2024.01.0410085-2538ORCID: /0000-0003-1336-7744/work/160390224https://hdl.handle.net/2164/23825We are grateful to the donors, donor families, and NHS Blood and Transplant service and the Cambridge Biorepository for Translational Medicine (CBTM) for access to human samples; Karolina Nilsson (Medicinal Chemistry, AstraZeneca) for providing the cytosolic phospholipase A2 inhibitor; and Julia Lindgren (Discovery Sciences, AstraZenca) for coordinating the RNA-sequencing workflow.135150328engarachidonic acidkidney damagekidney inflammationimaging mass cytometrylipidomicsmetabolic pathwaysR Medicine (General)Supplementary Informationhttps://ars.els-cdn.com/content/image/1-s2.0-S0085253824001686-mmc1.pdfhttps://ars.els-cdn.com/content/image/1-s2.0-S0085253824001686-mmc2.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S0085253824001686-mmc3.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S0085253824001686-mmc4.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S0085253824001686-mmc5.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S0085253824001686-mmc6.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S0085253824001686-mmc7.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S0085253824001686-mmc8.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S0085253824001686-mmc9.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S0085253824001686-mmc10.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S0085253824001686-mmc11.xlsxhttps://doi.org/10.1016/j.kint.2024.01.041R1Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function.Journal article10.1016/j.kint.2024.01.0411061