Alexandru-Crivac, Cristina N.Umeobika, ChristianLeikoski, NiinaJokela, JouniRickaby, Kirstie A.Grilo, André M.Sjö, PeterPlowright, Alleyn T.Idress, MohannadSiebs, EikeNneoyi-Egbe, AdaWahlsten, MattiSivonen, KaarinaJaspars, MarcelTrembleau, LaurentFewer, David PHoussen , Wael E.2017-11-162017-11-162017-10-04Alexandru-Crivac, C N, Umeobika, C, Leikoski, N, Jokela, J, Rickaby, K A, Grilo, A M, Sjö, P, Plowright, A T, Idress, M, Siebs, E, Nneoyi-Egbe, A, Wahlsten, M, Sivonen, K, Jaspars, M, Trembleau, L, Fewer, D P & Houssen , W E 2017, 'Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants', Chemical Communications, vol. 53, no. 77, pp. 10656-10659. https://doi.org/10.1039/C7CC05913B1359-7345ORCID: /0000-0001-6376-9077/work/72631833ORCID: /0000-0002-2426-6028/work/163664560http://hdl.handle.net/2164/9611This project was supported by grants from the ERC (no. 339367, MJ), BBSRC IBCatalyst (no. BB/M028526/1, MJ, WEH), BBSRC FoF (no. BB/M013669/1, MJ, WEH), IBioIC Exemplar (no. 2014-2-4, MJ, WEH), an AstraZeneca studentship (MJ, WEH, LT, KR), the Academy of Finland (no. 259505, DPF) and the SULSA leaders award (WEH). The authors like to thank the Aberdeen Proteomics Facility and the Aberdeen School of Natural and Computing Sciences MS Facility for LCMS analysis. Electronic supplementary information (ESI) available: Experimental section, Fig. S1–S60 and Tables S1–S3. See DOI: 10.1039/c7cc05913b41605404engQD ChemistryBiotechnology and Biological Sciences Research Council (BBSRC)BB/M028526/1BB/M013669/1European Research Council339367QDJournal article10.1039/C7CC05913B5377